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동국대학교

ACS Nano, Apr 21 2025, | https://doi.org/10.1021/acsnano.5c01457 Electromagnetized MXenes Enhance the Efficient Direct Reprogramming of Dopamine Neurons for Parkinson's Disease Therapy

Junyeop Kim ¹, Sumin Kim ¹, Yerim Hwang ¹, Saemin An ¹, Jeonghyun Park ¹, Yoo-Bin Kwon ², Byounggook Cho ¹, Daeyeol Kwon¹, Yunkyung Kim¹, Soi Kang ¹, Young-Kwan Kim ², Jongpil Kim¹

¹Institute for Stem Cells & Regenerative Medicine, Department of Chemistry, Dongguk University, Seoul 10326, Republic of Korea.
²Sustainable Nanochemistry Laboratory, Department of Chemistry, Dongguk University, Seoul 10326, Republic of Korea.

J.K., S.K., Y.H., and S.A. contributed equally to this work and share the first authorship.
Corresponding Authors : Young-Kwan Kim, Jongpil Kim

Abstract

MXenes, a two-dimensional transition metal carbide and nitride, have shown significant potential in various biological applications. In particular, the distinct properties of MXenes─including their functionalizable surface, biocompatibility, and conductive characteristics, make them highly promising materials for advancing biomedical technologies. Here, we report that MXene, under specific electromagnetic field (EMF) conditions, effectively promotes the direct lineage reprogramming of induced dopaminergic (iDA) neurons both in vitro and in vivo. Remarkably, we found that electromagnetized MXene leads to specific activation of histone acetylation during the induced dopaminergic neuronal reprogramming process and efficiently alleviates symptoms in a mouse model of Parkinson's disease (PD). Moreover, MXene-mediated electromagnetic stimulation effectively promotes the direct reprogramming of human iDA neurons from skin fibroblasts. Therefore, our study highlights MXene's application in cell reprogramming, offering promising advancements in regenerative medicine through improved efficiency and reliability.

논문정보

형식Research article
게재일2025년 04월 (BRIC 등록일 2025-04-23)
연구진국내 연구진
분야 생명과학 > 생화학

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