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Adv. Sci., 17 April 2025 | https://doi.org/10.1002/advs.202416771
Micro-Coil Neuromodulation at Single-Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures
Kayeon Kim 1, Xiyuan Liu 1 2, Bingdong Chang 2, Guanghui Li 1, Gwendoline A E Anand 2, Su Genelioglu 2, Alexandra Katherine Isis Yonza 1, Andrew J Whalen 3, Rune W Berg 1, Shelley I Fried 4 5, Anpan Han 2 *, Changsi Cai 1 *
1Department of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2200, Denmark.
2Department of Civil and Mechanical Engineering, Technical University of Denmark, Lyngby, 2800, Denmark.
3Department of Neurosurgery, Yale School of Medicine, New Haven, CT, 06510, USA.
4Boston VA Healthcare System, Boston, MA, 02130, USA.
5Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
2Department of Civil and Mechanical Engineering, Technical University of Denmark, Lyngby, 2800, Denmark.
3Department of Neurosurgery, Yale School of Medicine, New Haven, CT, 06510, USA.
4Boston VA Healthcare System, Boston, MA, 02130, USA.
5Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
*Corresponding authors: correspondence to Anpan Han or Changsi Cai
Abstract
Micromagnetic stimulation (µMS) emerges as a complementary method for neuromodulation. Despite major advances in neural interface technology, there are limited options for neural inhibition. Here, a microchip-based implantable micro-coil device is presented to achieve high spatial precision for cortical inhibition. Cortical in vivo two-photon imaging of spontaneous neural activity showed µMS reversibly suppressed single cells, and as µMS magnitude is increased, the suppressed cell population increased from 14% to 41%. At the circuit level, the average suppressed area is 0.05 mm2, seven times smaller than the activated area induced by micro-electrode stimulation (µES). It is discovered that neurons responded more strongly to µMS than to µES, which is exploited to effectively neutralize the neural excitation induced by concurrently delivered strong µES (80 µA). Moreover, µMS mitigates hyperactive neural firing caused by pharmacologically induced seizures, reducing seizure amplitude by 54%. These findings underscore the potential of µMS as a precise, effective, and versatile tool for localized neuromodulation with an effect of opposite polarity from µES. Complementing optogenetic and electrical stimulation for multi-functional neural interfaces, µMS holds promise as a unique neuroscience research tool and as a potential therapeutic intervention method for precisely suppressing hyperactive brain circuits.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-04-21)
- 국외 연구진
- 바이오·의료융합 > 바이오·의료융합 기타
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