한빛사
>
한빛사논문
한빛사논문
- 조회163
Adv. Funct. Mater., 03 April 2025 | https://doi.org/10.1002/adfm.202420870
Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno-Cancer Therapy
Sanghee Lee1, Seongchan Kim2, Eui-Sang Yu3, Sian Lee4, Min Jun Ko1, Hyojin Lee4, Dong-Hyun Kim1,5,6
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611 USA
2College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do, 52828 Republic of Korea
3Materials and Components Research Division, Electronics and Telecommunications Research Institute (ETRI), Daejeon, 34129 Republic of Korea
4Biomaterial Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792 Republic of Korea
5Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, 60611 USA
6Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, 60208 USA
S.L. and S.K. contributed equally to this work.
Corresponding Author : Dong-Hyun Kim
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611 USA
2College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do, 52828 Republic of Korea
3Materials and Components Research Division, Electronics and Telecommunications Research Institute (ETRI), Daejeon, 34129 Republic of Korea
4Biomaterial Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792 Republic of Korea
5Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, 60611 USA
6Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, 60208 USA
S.L. and S.K. contributed equally to this work.
Corresponding Author : Dong-Hyun Kim
Abstract
Non-thermal bioelectricity cancer therapy (BECT), utilizing high-voltage and high-frequency pulsed electric fields, represents a novel approach in oncological treatment. Herein, an electric pulse-regulated MXene-based nanozyme (MXenzyme)-catalyzed bioelectricity cancer cell eradication is presented while activating immunogenic responses for integrative BECT immunotherapy. Ti₃C₂ MXenzyme, the most conductive member of the MXene family, is synthesized and characterized for superior electrical properties in an aqueous environment. Incorporating MXenzyme into BECT significantly enhances irreversible cancer cell death and expands the ablation area compared to BECT alone. Computational modeling reveals that MXenzyme on cell membranes generates localized hotspots of current density and electric field (E-field) concentration during BECT application. MXenzyme catalytic effect in BECT induced three primary cytotoxic mechanisms: 1) direct membrane depolarization and irreversible poration, 2) disruption of voltage-gated ion channels, and 3) generation of cytotoxic reactive oxygen species. These combined mechanisms contributed to immunogenic cell death. Immunological profiling of the tumor microenvironment modulated by MXenzyme-BECT confirmed its profound cytotoxic impact and activation of a potent anti-tumor immune response. Translational potential of MXenzyme-BECT is evaluated using computational modeling-based pre-treatment planning and in combination with immune checkpoint inhibitor therapy. Findings underscore MXenzyme's pivotal role as a highly electric-regulated enzymatic catalyst, significantly enhancing BECT efficacy and advancing integrative BECT-immunotherapy strategies.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-04-20)
- 국내+국외 연구진
- 바이오·의료융합 > 다학제 융합/복합
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
