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한빛사논문
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Adv. Drug Deliv. Rev., Apr 15 2025, S0169-409X(25)00075-4 | https://doi.org/10.1016/j.addr.2025.115590
Nanodiamond-Based Sensing: A revolution for biosensors in capturing elusive bio-signals in living cells
Jiahua Zhang a,1, Linjie Ma a,1, Yong Hou a, Haoyi Ouyang a, Hyunsik Hong b, Kanghyeon Kim b, Heemin Kang b,c, Zhiqin Chu d,e
aDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China
bDepartment of Materials Science and Engineering and College of Medicine, Korea University, Seoul 02841, Republic of Korea
cCollege of Medicine, Korea University, Seoul 02841, Republic of Korea
dSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, China
eAdvanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, Hong Kong, China
1These authors made equal contributions to this work.
Corresponding authors: Heemin Kang, Zhiqin Chu
aDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China
bDepartment of Materials Science and Engineering and College of Medicine, Korea University, Seoul 02841, Republic of Korea
cCollege of Medicine, Korea University, Seoul 02841, Republic of Korea
dSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, China
eAdvanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, Hong Kong, China
1These authors made equal contributions to this work.
Corresponding authors: Heemin Kang, Zhiqin Chu
Abstract
Cells constantly produce elusive bio-signals, such as cellular forces, free radicals, and molecular interactions, that are important for understanding diseases and treatment effects. However, detecting these signals is challenging because of issues with sensitivity, specificity, and the complexity of biological systems. Owing to their unique properties, nanodiamonds have emerged as a promising platform for detecting such elusive bio-signals, providing enhanced precision and effectiveness in diagnostics and therapies. In this review, we explore the detection of intracellular elusive bio-signals using nitrogen-vacancy (NV) centers in nanodiamonds, presenting case studies on their applications in cell force, free radicals, molecular interactions, and nanoscale thermometry. Moreover, we explore the design and applications of nanodiamonds as nanocarriers in quantum sensors and drug delivery systems.
논문정보
- Review Paper
- 2025년 04월 (BRIC 등록일 2025-04-20)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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