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Bioresour. Technol., Apr 12 2025, S0960-8524(25)00504-8 | https://doi.org/10.1016/j.biortech.2025.132538
Electrostatically assembled maghemite nanoparticles-Lactobacillus plantarum: A novel hybrid for enhanced antioxidant, antimicrobial, and antibiofilm efficacy
Jayshri A. Shingade a,b, Navnath S. Padalkar b, Jae Hwan Shin b, Yeong Hyeock Kim c, Tae Jung Park c, Jong Pil Park b, Abhinandan R. Patil d
aCentre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur 416 006, India
bBasic Research Laboratory, Department of Food Science and Technology, GreenTechn-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong 17546, Republic of Korea
cDepartment of Chemistry, Research Institute of Chem-Bio Diagnostic Technology, Chung-Ang University, 84, Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
dDepartment of Pharmaceutics, D. Y. Patil Education Society (Deemed to Be University), Kolhapur 416 006, India
Corresponding authors : Jong Pil Park, Abhinandan R. Patil
aCentre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur 416 006, India
bBasic Research Laboratory, Department of Food Science and Technology, GreenTechn-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong 17546, Republic of Korea
cDepartment of Chemistry, Research Institute of Chem-Bio Diagnostic Technology, Chung-Ang University, 84, Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
dDepartment of Pharmaceutics, D. Y. Patil Education Society (Deemed to Be University), Kolhapur 416 006, India
Corresponding authors : Jong Pil Park, Abhinandan R. Patil
Abstract
Excessive antibiotic use contributes to oxidative stress and microbial imbalance, leading to increased growth of pathogens and biofilm formation. To address this, we developed a novel electrostatically assembled hybrid of maghemite nanoparticles and Lactobacillus plantarum (MNPs-LAB) as a multifunctional agent. Structural and surface interactions were confirmed through X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS), while transmission electron microscopy (TEM) and field emission scanning electron microscopy (FESEM) analyses revealed a uniform distribution of MNPs on the LAB surface. The MNPs-LAB hybrid exhibited strong antioxidant activity (71.45 % at 500 µg/mL) and enhanced antimicrobial performance against Listeria monocytogenes. In addition, the hybrid inhibited biofilm formation and effectively eradicated preformed biofilms of Staphylococcus succinus, Listeria monocytogenes, Escherichia coli, and Salmonella thompson. Notably, the low cytotoxicity observed in Caco-2 cells indicated good biocompatibility with intestinal epithelial cells. These results highlight the potential of MNPs-LAB hybrid as a safe and effective therapeutic candidate for combating oxidative stress, microbial infections, and biofilm-associated challenges.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-04-15)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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