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J. Control. Release, Apr 12 2025, S0168-3659(25)00340-2 | https://doi.org/10.1016/j.jconrel.2025.113720 Regulated cell death mechanisms in mitochondria-targeted phototherapy

Qihang Ding ^a,b, Hyeonji Rha ^b, Changyu Yoon ^b, Yujin Kim ^b, So Jin Hong ^c, Hui Ju Kim ^c, Yang Li ^a, Min Hee Lee ^c, Jong Seung Kim ^b

^aSchool of Chemical Engineering & Pharmacy, Pharmaceutical Research Institute, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan 430205, China
^bDepartment of Chemistry, Korea University, Seoul 02841, Republic of Korea
^cDepartment of Chemistry, Chung-Ang University, Seoul 06974, Republic of Korea

Corresponding authors: Yang Li, Min Hee Lee, Jong Seung Kim

Abstract

Phototherapy, comprising photodynamic therapy (PDT) and photothermal therapy (PTT), was first introduced over a century ago and has since evolved into a versatile cancer treatment modality. While numerous studies have explored regulated cell death (RCD) mechanisms induced by phototherapy, a comprehensive synthesis centered on mitochondria-targeted phototherapeutic strategies and agents as mediators of RCD is still lacking. This review provides a systematic and in-depth analysis of recent advances in mitochondria-centered mechanisms driving phototherapy-induced death pathways, including apoptosis, autophagy, pyroptosis, immunogenic cell death, ferroptosis, and cuproptosis. We highlight the critical role of mitochondria as central regulators of these death pathways in response to phototherapeutic interventions. Moreover, we discuss fundamental design strategies for developing precision-targeted phototherapeutic materials to enhance efficacy and minimize off-target effects. Finally, we identify prevailing challenges and propose future research directions to address these hurdles, paving the way for next-generation mitochondria-targeted phototherapy as a highly effective strategy for cancer management.

논문정보

형식Research article
게재일2025년 04월 (BRIC 등록일 2025-04-15)
연구진국내(교신)+국외 연구진
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