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Nat. Hum. Behav., 14 April 2025 | https://doi.org/10.1038/s41562-025-02155-z
Polygenic overlap between subjective well-being and psychiatric disorders and cross-ancestry validation
Jin Young Jung 1,2, Yeeun Ahn 1, Jung-Wook Park 1, Kyeongmin Jung1,3, Soyeon Kim1, Soohyun Lim4, Sang-Hyuk Jung 5, Hyejin Kim1, Beomsu Kim1, Mi Yeong Hwang6, Young Jin Kim6, Woong-Yang Park7, Aysu Okbay8, Kevin S. O’Connell9, Ole A. Andreassen9, Woojae Myung3,10,11 & Hong-Hee Won1,6,11
1Department of Digital Health, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea.
2Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
3Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
4Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea.
5Department of Medical Informatics, Kangwon National University College of Medicine, Chuncheon, South Korea.
6Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Chungcheongbuk-do, South Korea.
7Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
8Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
9Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
10Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
11These authors contributed equally: Woojae Myung, Hong-Hee Won.
Corresponding authors
Correspondence to Woojae Myung or Hong-Hee Won.
1Department of Digital Health, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea.
2Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
3Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
4Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea.
5Department of Medical Informatics, Kangwon National University College of Medicine, Chuncheon, South Korea.
6Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Chungcheongbuk-do, South Korea.
7Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
8Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
9Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
10Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
11These authors contributed equally: Woojae Myung, Hong-Hee Won.
Corresponding authors
Correspondence to Woojae Myung or Hong-Hee Won.
Abstract
Subjective well-being (SWB) is important for understanding human behaviour and health. Although the connection between SWB and psychiatric disorders has been studied, common genetic mechanisms remain unclear. This study aimed to explore the genetic relationship between SWB and psychiatric disorders. Bivariate causal mixture modelling (MiXeR), polygenic risk score (PRS) and Mendelian randomization (MR) analyses showed substantial polygenic overlap and associations between SWB and the psychiatric disorders. Subsequent replication studies in East Asian populations confirmed the polygenic overlap between schizophrenia and SWB. The conditional and conjunctional false discovery rate analyses identified additional or shared genetic loci associated with SWB or psychiatric disorders. Functional annotation revealed enrichment of specific brain tissues and genes associated with SWB. The identified genetic loci showed cross-ancestry transferability between the European and Korean populations. Our findings provide valuable insights into the common genetic mechanisms underlying SWB and psychiatric disorders.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-04-15)
- 국내(교신)+국외 연구진
- 의약학 > 유전 및 유전체의학
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