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Bioact. Mater., Available online 27 March 2025 | https://doi.org/10.1016/j.bioactmat.2025.03.018
Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration
Yu Bin Lee a,b,1, Mi-Lang Kyun a,1, Young Ju Lee c, Hye-Eun Shim c,d, Kang Moo Huh c,e,2, Sun-Woong Kang b,d,2
aCenter for Global Biopharmaceutical Research, Korea Institute of Toxicology, Daejoen, 34114, Republic of Korea
bSchool of Korea Institute of Toxicology, University of Science and Technology, Daejeon, 34114, Republic of Korea
cDepartment of Polymer Science and Engineering, Chungnam National University, Daejeon, 34134, Republic of Korea
dCenter for Biomimetic Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea
eDepartment of Materials Science and Engineering, Chungnam National University, Daejeon, 34134, Republic of Korea
1These authors contributed equally to this study as the first authors.
2These authors contributed equally to this study as corresponding authors.
Corresponding authors: Kang Moo Huh, Sun-Woong Kang
aCenter for Global Biopharmaceutical Research, Korea Institute of Toxicology, Daejoen, 34114, Republic of Korea
bSchool of Korea Institute of Toxicology, University of Science and Technology, Daejeon, 34114, Republic of Korea
cDepartment of Polymer Science and Engineering, Chungnam National University, Daejeon, 34134, Republic of Korea
dCenter for Biomimetic Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea
eDepartment of Materials Science and Engineering, Chungnam National University, Daejeon, 34134, Republic of Korea
1These authors contributed equally to this study as the first authors.
2These authors contributed equally to this study as corresponding authors.
Corresponding authors: Kang Moo Huh, Sun-Woong Kang
Abstract
Cyclodextrins (CDs), characterized by their unique cyclic oligosaccharide structure and exceptional capacity for molecular encapsulation through host-guest interactions, have garnered significant attention as versatile building blocks in advanced biomaterials. This review explores the application of CD-based biomaterials in tissue engineering and regenerative medicine, emphasizing their synthesis, physicochemical characterization, biocompatibility, and translational potential. Special emphasis is placed on the development of CD-modified hydrogels, their interaction with host-guest molecules, and their use in advanced therapeutic strategies. Additionally, we discuss various fabrication methods for CD-based biomaterials, including physical and covalent crosslinking, self-assembly, and enzymatic crosslinking, each providing unique properties suited for advanced therapeutic strategies. Safety considerations and potential regulatory challenges associated with these materials are also examined. By providing a comprehensive overview of recent advancements, this review aims to highlight the promising role of cyclodextrins as multifunctional tools in enhancing tissue repair and regeneration, paving the way for innovative therapeutic solutions in clinical settings.
논문정보
- Review Paper
- 2025년 03월 (BRIC 등록일 2025-04-14)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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