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Yuan-Yuan ZhaoYuan-Yuan Zhao
이화여자대학교
Angew. Chem.-Int. Edit., Apr 09 2025, | https://doi.org/10.1002/anie.202506412
A Hypoxia-Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High-Specificity Cancer Phototherapy
Yuan-Yuan Zhao,†,a,b Yihui Xu,†,a Xiaojun Zhang,†,a Zixuan Chen,a Heejeong Kim,b Xingshu Li,*,a and Juyoung Yoon*,b,c
[a] Dr. Y Zhao,† Y Xu,† X Zhang,† Z Chen, Prof. X Li*
Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University 350108 Fuzhou (China)
[b] H Kim, Prof. J Yoon*
[a] Dr. Y Zhao,† Y Xu,† X Zhang,† Z Chen, Prof. X Li*
Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University 350108 Fuzhou (China)
[b] H Kim, Prof. J Yoon*
Department of Chemistry and Nanoscience, Ewha Womans University 03760 Seoul (Korea)
[c] Prof. J Yoon*
[c] Prof. J Yoon*
Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University 03760 Seoul (Korea)
[†] These authors contributed equally to this work.
Corresponding Author: Juyoung Yoon
[†] These authors contributed equally to this work.
Corresponding Author: Juyoung Yoon
Abstract
Considering that hypoxia is strongly connected with tumor proliferation, metastasis, invasion, and drug resistance, it is of significant implication for alleviating the effects of hypoxia in tumor treatment. The negligible oxygen-dependent nature of type I photosensitizers (PSs) has made them appropriate candidates for the treatment of hypoxic tumors. However, the lack of effective molecular design approaches, the phototoxicity of PSs to normal tissue before and after treatment, and the drawbacks of poor hydrophilicity severely hinder the development of PSs in hypoxic tumor therapy. Thus, developing a hydrophilic PS with good hypoxia resistance and minimal side effects is an urgent but challenging problem. Herein, we present a nanotheranostic (NanoPcN8O) based on the self-assembly of a hydrophilic phthalocyanine (PcN8O), a hypoxia-responsive bioreductive photosensitizer suitable for activatable photoacoustic (PA) imaging and tumor therapy. Hypoxic regions in various tumors exhibit strong reductive capability, and only in such condition did NanoPcN8O feature multiple N-oxide groups that could be bioreduced to yield the product NanoPcN8 with abundant electron-rich tertiary amine groups, which switches on the type I photodynamic and photothermal effects. Better still, NanoPcN8O achieved hypoxia-induced selective PA imaging in a preclinical model. Based on these merits, such nanotheranostic demonstrated remarkable phototherapeutic efficiency with high biosafety.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-05-09)
- 국내(교신)+국외 연구진
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