한빛사
>
한빛사논문
한빛사논문
- 조회75
Nano Lett., Apr 08 2025, | https://doi.org/10.1021/acs.nanolett.5c00069
Soft 3D Bioelectrodes for Intraorganoid Signal Monitoring in Cardiac Models
Young-Geun Park 1, Sumin Kim 2, Sungjin Min 3,4, Enji Kim 2, Dayeon Kim 2,5,6,7, Yo Han Cho 2, Suran Kim 3, Hyebin Joo 3, Inhea Jeong 2, Jung Ah Lim 6,7,8, Sangmin Lee 9, Seung-Woo Cho 3,8,10, Jang-Ung Park 2,5,8,10,11
1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
2Nano Science Technology Institute, Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.
3Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
4Department of MetaBioHealth, Sungkyunkwan University, Suwon 16419, Republic of Korea.
5Yonsei-KIST Convergence Research Institute, Seoul 03722, Republic of Korea.
6Soft Hybrid Materials Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
7Division of Nanoscience and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, Republic of Korea.
8Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea.
9Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
10Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea.
11Department of Neurosurgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Y.-G.P., S.K., S.M., and E.K. contributed equally to this work.
Corresponding Authors : Seung-Woo Cho, Jang-Ung Park
1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
2Nano Science Technology Institute, Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.
3Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
4Department of MetaBioHealth, Sungkyunkwan University, Suwon 16419, Republic of Korea.
5Yonsei-KIST Convergence Research Institute, Seoul 03722, Republic of Korea.
6Soft Hybrid Materials Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
7Division of Nanoscience and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, Republic of Korea.
8Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea.
9Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
10Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea.
11Department of Neurosurgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Y.-G.P., S.K., S.M., and E.K. contributed equally to this work.
Corresponding Authors : Seung-Woo Cho, Jang-Ung Park
Abstract
Continuous monitoring of physiological activities within the internal regions of three-dimensional (3D) organoids holds significant promise for advancing organoid-based research. However, conventional methods are constrained to capturing signals from the peripheral surfaces of organoids, limiting insights into internal dynamics. Here, we present a soft 3D bioelectrode platform for continuous intraorganoid signal monitoring. These bioelectrodes, formed via 3D printing of liquid metal, are designed with customizable geometric parameters, including height and diameter, to adapt to various organoid structures. The tissue-comparable softness of the electrodes minimizes damage to cardiac organoids, ensuring a stable interface for reliable signal recording even under dynamic deformations caused by rhythmic contractions or displacements in aqueous environments. The array configuration enables simultaneous electrocardiogram (ECG) recordings from 32 organoids. Demonstrating real-time monitoring of drug-induced ECG responses, this scalable platform highlights its potential for high-throughput drug screening.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-04-10)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
