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유노을Roh-Eul Yoo

서울대학교병원

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Nat. Commun., 09 April 2025 | https://doi.org/10.1038/s41467-025-58726-1 Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans

Roh-Eul Yoo^1,2,12, Jun-Hee Kim^3,12, Hyo Youl Moon^4,12, Jae Yeon Park⁴, Seongmin Cheon^5,6, Hyun-Suk Shin⁶, Dohyun Han^6,7,8, Yukyoum Kim^4,13, Sung-Hong Park^9,13& Seung Hong Choi^1,2,10,11,13

¹Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea.
²Department of Radiology, Seoul National University Hospital, Seoul, South Korea.
³Medical Research Center, Seoul National University, Seoul, South Korea.
⁴Department of Physical Education, Seoul National University, Seoul, South Korea.
⁵School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.
⁶Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
⁷Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
⁸Department of Medicine, Seoul University College of Medicine, Seoul, Republic of Korea.
⁹Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
¹⁰Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea.
¹¹School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea.
¹²These authors contributed equally: Roh-Eul Yoo, Jun-Hee Kim, Hyo Youl Moon.
¹³These authors jointly supervised this work: Yukyoum Kim, Sung-Hong Park, Seung Hong Choi.

Corresponding authors
Correspondence to Yukyoum Kim, Sung-Hong Park or Seung Hong Choi.

Abstract

Regular voluntary exercise has been shown to increase waste transport through the glymphatic system in mice. Here, we investigate the impact of physical exercise on both upstream and downstream brain waste clearance in healthy volunteers via noninvasive MR imaging. Putative glymphatic influx, evaluated using intravenous contrast-enhanced dynamic T1 mapping, increases significantly at the putamen after 12 weeks of long-term exercise using a cycle ergometer. The putative meningeal lymphatic vessel size and flow, measured by intravenous contrast-enhanced black-blood imaging and IR-ALADDIN technique, increase significantly after long-term exercise. Plasma proteomics reveals significant changes in inflammation-related and immune-related proteins (down-regulated: S100A8, S100A9, PSMA3, and DEFA1A3; up-regulated: J chain) after long-term exercise, which correlate with putative glymphatic influx or mLV flow. Our results suggest that increased glymphatic and mLV flow may be the potential mechanism underlying the neuroprotective effects of exercise on cognition, highlighting the importance of long-term, regular exercise.

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