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Adv. Healthc. Mater., Apr 08 2025, | https://doi.org/10.1002/adhm.202405179
A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals
Hongseong Shin 1,2, Kyungtae Kim 3, Jaeseung Lee 2,4, Johyeon Nam 5, Eunha Baeg 1, Chaeyeon You 1, Hanseul Choi 4, Minji Kim 3, Chun Kee Chung 6, Jae Geun Kim 5, Jong Hyun Ahn 7, Miryung Han 5, Jibum Kim 2,4, Sungchil Yang 8, Sung Q Lee 9,10, Sunggu Yang 1,2,3
1Department of Nanobioengineering, Incheon National University, Incheon, 22012, Republic of Korea.
2Center for Brain-Machine Interface, Incheon National University, Incheon, 22012, Republic of Korea.
3gBrain Inc., Incheon, 21984, Republic of Korea.
4Department of Computer Science and Engineering, Incheon National University, Incheon, 22012, Republic of Korea.
5Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, Republic of Korea.
6Department of Neurosurgery, Seoul National University College of Medicine, Kowloon, Hong Kong.
7School of Electrical & Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
8Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, 00000, Hong Kong.
9Brainlinks Creative Research Laboratory, Electronics and Telecommunications Research Institute, Daejeon, 34129, South Korea.
10Department of Mechanical Engineering, San Diego State University, San Diego, CA, 92182, USA.
Corresponding Authors: Sungchil Yang, Sung Q Lee, Sunggu Yang
1Department of Nanobioengineering, Incheon National University, Incheon, 22012, Republic of Korea.
2Center for Brain-Machine Interface, Incheon National University, Incheon, 22012, Republic of Korea.
3gBrain Inc., Incheon, 21984, Republic of Korea.
4Department of Computer Science and Engineering, Incheon National University, Incheon, 22012, Republic of Korea.
5Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, Republic of Korea.
6Department of Neurosurgery, Seoul National University College of Medicine, Kowloon, Hong Kong.
7School of Electrical & Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
8Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, 00000, Hong Kong.
9Brainlinks Creative Research Laboratory, Electronics and Telecommunications Research Institute, Daejeon, 34129, South Korea.
10Department of Mechanical Engineering, San Diego State University, San Diego, CA, 92182, USA.
Corresponding Authors: Sungchil Yang, Sung Q Lee, Sunggu Yang
Abstract
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is involved in motor abnormality, primarily arising from the degeneration of dopaminergic neurons. Previous studies have examined the electrotherapeutic effects of PD using various methodological contexts, including live conditions, wireless control, diagnostic/therapeutic aspects, removable interfaces, or biocompatible materials, each of which is separately utilized for testing the diagnosis or alleviation of various brain diseases. Here, a cortical surface implant designed to improve motor function in freely moving PD animals is presented. This implant, a minimally invasive system equipped with a graphene electrode array, is the first integrated system to exhibit biocompatibility, wearability, removability, target specificity, and wireless control. The implant positioned at the motor cortical surface activates the motor cortex to maximize therapeutic effects and minimize off-target effects while monitoring motor activities. In PD animals, cortical motor surface stimulation restores motor function and brain waves, which corresponds to potentiated synaptic responses. Furthermore, these changes are associated with the upregulation of metabotropic glutamate receptor 5 (mGluR5, Grm5) and D5 dopamine receptor (D5R, Drd5) genes in the glutamatergic synapse. The newly designed wireless neural implant demonstrates capabilities in both real-time diagnostics and targeted therapeutics, suggesting its potential as a wireless system for biomedical devices for patients with PD and other neurodegenerative diseases.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-04-09)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 뇌인지과학
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