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Biosens. Bioelectron., Apr 01 2025, 280 S0956-5663(25)00306-9 | https://doi.org/10.1016/j.bios.2025.117432
Recent advances in bioreceptor-based sensing for extracellular vesicle analysis
Myoung Gyu Kim a,1, Soo Min Ryu b,1, Yong Shin a,b
aDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei Ro, Seodaemun-gu, Seoul, 03722, Republic of Korea
bLife Science and Biotechnology, Underwood International College, Yonsei University, 50 Yonsei Ro, Seodaemun-gu, Seoul, 03722, Republic of Korea
1These authors (M.G. Kim and S.M. Ryu) contributed equally to this work.
Corresponding author: Yong Shin
aDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei Ro, Seodaemun-gu, Seoul, 03722, Republic of Korea
bLife Science and Biotechnology, Underwood International College, Yonsei University, 50 Yonsei Ro, Seodaemun-gu, Seoul, 03722, Republic of Korea
1These authors (M.G. Kim and S.M. Ryu) contributed equally to this work.
Corresponding author: Yong Shin
Abstract
Extracellular vesicles (EVs) are nanoscale, membrane-bound structures secreted by various cell types into biofluids. They show great potential as biomarkers for disease diagnostics, owing to their ability to carry molecular cargo that reflects their cellular origin. However, the inherent heterogeneity of EVs in terms of size, composition, and source presents significant challenges for reliable detection and analysis. Recent advances in bioreceptor-based biosensor technologies provide promising solutions by offering high sensitivity and specificity in EV detection and characterization. These technologies address the limitations of conventional methods, such as ultracentrifugation and bulk analysis. Biosensors utilizing antibodies, aptamers, peptides, lectins, and molecularly imprinted polymers enable precise detection of EV subpopulations by targeting specific EV surface markers, including proteins, lipids, and glycans. Additionally, these biosensors support multiplexed and real-time analysis while preserving the structural integrity of EVs. This review highlights the transformative potential of combining modern biosensing tools with bioreceptor technologies to advance EV research and diagnostics, paving the way for innovations in disease diagnostics and therapeutic monitoring.
논문정보
- Review Paper
- 2025년 04월 (BRIC 등록일 2025-04-07)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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