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Environ. Sci. Technol. , Mar 30 2025, | https://doi.org/10.1021/acs.est.4c14065 Airborne Influenza Virus Surveillance Platform Using Paper-Based Immunosensors and a Growth-Based Virus Aerosol Concentrator

Chanhwi Park ¹, Junbeom Jang², Jaesung Jang^1,2,3

¹Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
²Department of Mechanical Engineering, UNIST, Ulsan 44919, Republic of Korea.
³Department of Civil, Urban, Earth, and Environmental Engineering, UNIST, Ulsan 44919, Republic of Korea.

C.P. and J.J. contributed equally to this work.
Corresponding Author : Jaesung Jang

Abstract

The measurement of respiratory viruses in indoor air is critical for effectively preventing the spread of diseases. This is typically accomplished by counting the nucleic acids or plaques of air-sampled viruses. Herein, we present a growth-based airborne virus surveillance (G-AVS) platform based on paper-based electrochemical immunosensors for targeting hemagglutinin (HA) and nucleoprotein (NP), and water-condensation air sampling for the quantitative measurement of airborne influenza viruses. The measurements, compared with RT-qPCR, demonstrated consistency between the two. In the measurements of airborne influenza viruses conducted in an elementary school using G-AVS, 23% (4/17) of indoor air samples were positive, with concentrations ranging from 1.7 × 10⁴ to 1.6 × 10⁶ gene copies/m³, while losses in the HA relative to NP were 48-75% at a relative humidity of 27.0-36.8% and 60 min air sampling, similar to infectivities reported in the literature. This platform has the potential for rapid and cost-effective airborne virus measurement.

논문정보

형식Research article
게재일2025년 03월 (BRIC 등록일 2025-04-03)
연구진국내 연구진
분야 바이오·의료융합 > 다학제 융합/복합

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