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Adv. Healthc. Mater., Mar 24 2025, | https://doi.org/10.1002/adhm.202403229
Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells
Gwang-Bum Im 1, Jae Gyeong Lee 2,3, Hosub Lim 4, Jae-Won Lee 5, Hyun Su Park 1, Yongju Kim 6, Nauman Asad 5, Hak-Rin Kim 5,7, Jeong Jae Wie 2,3,8,9,10,11,12, Suk Ho Bhang 1
1School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
2Department of Organic and Nano Engineering, Hanyang University, Seoul, 04763, Republic of Korea.
3Human-Tech Convergence Program, Hanyang University, Seoul, 04763, Republic of Korea.
4Division of Engineering in Medicine and Renal Division, Department of Medicine, Harvard Medical School, Brigham Women's Hospital, Boston, MA, 02114, USA.
5School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea.
6Department of Polymer Science and Engineering, Inha University, Incheon, 22212, Republic of Korea.
7School of Electronics Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea.
8The Research Institute of Industrial Science, Hanyang University, Seoul, 04763, Republic of Korea.
9Department of Chemical Engineering, Hanyang University, Seoul, 04763, Republic of Korea.
10Institute of Nano Science and Technology, Hanyang University, Seoul, 04763, Republic of Korea.
11Department of Chemical Engineering, State University of New York College of Environmental Science and Forestry, Syracuse, NY, 13210, USA.
12The Michael M. Szwarc Polymer Research Institute, State University of New York College of Environmental Science and Forestry, Syracuse, NY, 13210, USA.
1School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
2Department of Organic and Nano Engineering, Hanyang University, Seoul, 04763, Republic of Korea.
3Human-Tech Convergence Program, Hanyang University, Seoul, 04763, Republic of Korea.
4Division of Engineering in Medicine and Renal Division, Department of Medicine, Harvard Medical School, Brigham Women's Hospital, Boston, MA, 02114, USA.
5School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea.
6Department of Polymer Science and Engineering, Inha University, Incheon, 22212, Republic of Korea.
7School of Electronics Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea.
8The Research Institute of Industrial Science, Hanyang University, Seoul, 04763, Republic of Korea.
9Department of Chemical Engineering, Hanyang University, Seoul, 04763, Republic of Korea.
10Institute of Nano Science and Technology, Hanyang University, Seoul, 04763, Republic of Korea.
11Department of Chemical Engineering, State University of New York College of Environmental Science and Forestry, Syracuse, NY, 13210, USA.
12The Michael M. Szwarc Polymer Research Institute, State University of New York College of Environmental Science and Forestry, Syracuse, NY, 13210, USA.
G.-B.I. and J.G.L. contributed equally to this work.
Corresponding Authors: Jeong Jae Wie, Suk Ho Bhang
Corresponding Authors: Jeong Jae Wie, Suk Ho Bhang
Abstract
Replicating the complex mechanical forces of muscle movement and fluid flow in in vitro cell culture systems is crucial for understanding cell differentiation and development. However, previous research focused on cell differentiation on static micro/nanotextures without a force field or flat 2-dimensional substrates under a continuous in-plane mechanical force. In this study, cell differentiation is reported using a spatial geometric platform that can periodically modulate complex mechanical forces through a custom-made soft pneumatic device (SPD) to mimic the interfaces between periosteum and interstitial fluid. To elucidate fluidic dynamics and cell fates relevant to bone physiology, the platform exhibited distinct functional responses based on mechanical force levels: low mechanotransduction induced mesenchymal stem/progenitor cells differentiation into osteoprogenitor cells (≈1.5-fold increase in osteo-differentiation), while high mechanotransduction resulted in structural disruptions resembling cell detachment without protein degradation (≈2-fold increase in effective cell detachment). Numerical simulations of SPD elucidated the principal mechanical components for programmable cell differentiation and detachment by deconvoluting the in-plane and out-of-plane mechanical forces of the SPD complex mode. This study offers comprehensive and novel insights into the correlation between mechanical forces and cell differentiation, recovery, and injury in organisms.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-25)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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