Dang Du Nguyen (성균관대학교) | 한빛사논문 > 한빛사

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조회123

Dang Du NguyenDang Du Nguyen

성균관대학교

Biosens. Bioelectron., Mar 10 2025, 278 S0956-5663(25)00235-0 | https://doi.org/10.1016/j.bios.2025.117361 Recent advances in dynamic single-molecule analysis platforms for diagnostics: Advantages over bulk assays and miniaturization approaches

Dang Du Nguyen ^a,b, Fedor Shuklin ^c, Elena Barulina ^c,d, Hristina Albitskaya ^c, Sergey Novikov ^c, Alexander I. Chernov ^d,e, Inki Kim^a,b,f, Aleksandr Barulin^c

^aDepartment of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, 16419, Republic of Korea
^bDepartment of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea
^cMoscow Center for Advanced Studies, Kulakova str. 20, Moscow, 123592, Russia
^dRussian Quantum Center, Moscow, 121205, Russia
^eCenter for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia
^fDepartment of MetaBioHealth, Sungkyunkwan University, Suwon, 16419, Republic of Korea

Corresponding authors: Alexander I. Chernov, Inki Kim, Aleksandr Barulin

Abstract

Single-molecule science is a unique technique for unraveling molecular biophysical processes. Sensitivity to single molecules provides the capacity for the early diagnosis of low biomarker amounts. Furthermore, the miniaturization of instruments for portable diagnostic tools toward point-of-care testing (POCT) is a crucial development in this field. Herein, we discuss recent developments in single-molecule sensing platforms and their advantages for diagnostics over bulk measurements including molecular size measurements, interaction dynamics, and fast biomarker sensing and sequencing at low concentrations. We highlight the capabilities of dynamic optical and electrical sensing platforms for single-biomolecule and single-vesicle monitoring associated with neurodegenerative disorders, viral diseases, cancers, and more. Current approaches to instrument miniaturization have brought technology closer to portable diagnostics settings via smartphone-based devices, multifunctional portable microscopes, handheld electrical circuit devices, and remote single-molecule assays. Finally, we provide an overview of the clinical applications of single-molecule sensors in POCT assays. Altogether, single-molecule analyses platforms exhibit significant potential for the development of novel portable healthcare devices.

논문정보

형식Review Paper
게재일2025년 03월 (BRIC 등록일 2025-03-24)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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