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Adv. Sci., Mar 20 2025, | https://doi.org/10.1002/advs.202413786 Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning-Based Advanced Perspectives

Sung-Hyun Kim ^{1 †}, Sumin Yang ^{1 †}, Jeehye Jung ¹, Jeonghyeon Choi¹, Mingon Kang ², Jae-Yeol Joo ^1,*

¹Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do, 15588, Republic of Korea.
²Department of Computer Science, University of Nevada, Las Vegas, NV, 89154, USA.

^†S.-H. K. and S. Y. contributed equally to this work.

^*Corresponding author: correspondence to Jae-Yeol Joo

Abstract

Mental disorders are a representative type of brain disorder, including anxiety, major depressive depression (MDD), and autism spectrum disorder (ASD), that are caused by multiple etiologies, including genetic heterogeneity, epigenetic dysregulation, and aberrant morphological and biochemical conditions. Psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have been renewed as fascinating treatment options and have gradually demonstrated potential therapeutic effects in mental disorders. However, the multifaceted conditions of psychiatric disorders resulting from individuality, complex genetic interplay, and intricate neural circuits impact the systemic pharmacology of psychedelics, which disturbs the integration of mechanisms that may result in dissimilar medicinal efficiency. The precise prescription of psychedelic drugs remains unclear, and advanced approaches are needed to optimize drug development. Here, recent studies demonstrating the diverse pharmacological effects of psychedelics in mental disorders are reviewed, and emerging perspectives on structural function, the microbiota-gut-brain axis, and the transcriptome are discussed. Moreover, the applicability of deep learning is highlighted for the development of drugs on the basis of big data. These approaches may provide insight into pharmacological mechanisms and interindividual factors to enhance drug discovery and development for advanced precision medicine.

논문정보

형식Review Paper
게재일2025년 03월 (BRIC 등록일 2025-03-21)
연구진국내(교신)+국외 연구진
분야 생명과학 > 유전학

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