김민아 (고려대학교, 한국과학기술연구원 (KIST)) | 한빛사논문 > 한빛사

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조회105

김민아Mina Kim

고려대학교, 한국과학기술연구원 (KIST)

Chem. Eng. J., Volume 509, 1 April 2025, 161118 | https://doi.org/10.1016/j.cej.2025.161118 Length-encoded rod-shaped magnetic particle-based multipurpose immuno- and molecular assay system for rapid and accurate diagnostics: VEUS

Mina Kim ^a,b,1, Jiyeong Kim ^c,1, Daekyoung Moon ^c, Seungmo Koo ^c, Heelak Choi ^c, Hanna Yoon ^d,e, Young Sun Ro ^d,e,f, Byung-Mo Oh ^g,h,i, Sang Hoon Song ^j,k, Yoo-Bok Cho ^c, Nakwon Choi ^{a,b,l,m,n,o,p}, Yong-Gyun Jung ^c

^aKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, South Korea
^bCenter for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, South Korea
^cR&D Center, EzDiatech Inc., Anyang 14055, South Korea
^dDepartment of Emergency Medicine, Seoul National University Hospital, Seoul 03080, South Korea
^eLaboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul 03080, South Korea
^fDepartment of Emergency Medicine, College of Medicine, Seoul National University, Seoul 03080, South Korea
^gDepartment of Rehabilitation Medicine, Seoul National University Hospital, Seoul 03080, South Korea
^hDepartment of Rehabilitation Medicine, College of Medicine, Seoul National University, Seoul 03080, South Korea
ⁱInstitute on Aging, Seoul National University, Seoul 03080, South Korea
^jDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul 03080, South Korea
^kDepartment of Laboratory Medicine, College of Medicine, Seoul National University, Seoul 03080, South Korea
^lDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, South Korea
^mDepartment of Convergence Medicine, College of Medicine, Korea University, Seoul 02841, South Korea
ⁿInstitute of Human Genetics, College of Medicine, Korea University, Seoul 02841, South Korea
^oResearch Institute for Convergence Biomedical Science, College of Medicine, Korea University, Seoul 02841, South Korea
^pBio-Medical Research Center, Korea University Guro Hospital, Seoul 08308, South Korea

¹These authors contributed equally.
Corresponding authors : Nakwon Choi, Yong-Gyun Jung

Abstract

In the biomedical field, there is increasing demand to combine the capabilities of POCTs with precision diagnostics for timely medical interventions. While precision diagnostics provide high sensitivity and multiplexing, they require at least a day for turnaround and involve costly, bulky equipment and skilled operators. Existing POCTs face challenges in concurrently achieving high sensitivity, accuracy, multiplex capability, and rapidity. A platform enabling immuno- and molecular diagnostics would enhance diagnostic and prognostic precision. We present VEUS (Versatile, Easy, User-friendly System), which integrates the benefits of POCTs and precision diagnostics. VEUS features four key components: 1) full automation of the assay workflow, 2) circumferentially focusing illumination with 1× imaging, 3) high-throughput AI-based decoding and image processing, and 4) length-encoded rod-shaped magnetic particles. These innovations yield ten times higher optical sensitivity than conventional microscopy and offer a universal, ready-to-commercialized platform capable of performing both immuno- and molecular diagnostics. Demonstrating broad clinical applications, we present this dual feature by its application in diagnosing traumatic brain injury and sepsis using immunoassays and respiratory viral infections by a molecular assay based on the CRISPR/Cas system. VEUS has the potential to significantly improve patient outcomes by providing rapid, accurate diagnostics at the point of care.

논문정보

형식Research article
게재일2025년 04월 (BRIC 등록일 2025-03-21)
연구진국내 연구진
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