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Nat. Commun., Published: 19 March 2025 | https://doi.org/10.1038/s41467-025-57631-x
Clade-specific extracellular vesicles from Akkermansia muciniphila mediate competitive colonization via direct inhibition and immune stimulation
Moon-Gi Hong1,7, Eun-Ji Song2,7, Hye Jin Yoon3,7, Won-Hyong Chung2, Hae Yeong Seo3, Dohak Kim1, Dokyung Lee1, Jae-Gu Seo1, Hayoung Lee4,5, Seung Il Kim4, Gwang Joong Kim6, Kil-Nam Kim6, Sang-Nam Lee1, Kwang Soon Kim3 & Young-Do Nam2
1R&D Center, Enterobiome Inc., 814 Siksa-dong, Ilsandong-gu, Goyang-si, Republic of Korea.
2Research Group of Personalized Diet, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, Republic of Korea.
3Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
4Digital Omics Research Center, Korea Basic Science Institute, Cheongju, Republic of Korea.
5Critical Diseases Diagnostics Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
6Gwangju Center, Korea Basic Science Institute (KBSI), Gwangju, Republic of Korea.
7These authors contributed equally: Moon-Gi Hong, Eun-Ji Song, Hye Jin Yoon.
Corresponding authors
Correspondence to Sang-Nam Lee, Kwang Soon Kim or Young-Do Nam.
1R&D Center, Enterobiome Inc., 814 Siksa-dong, Ilsandong-gu, Goyang-si, Republic of Korea.
2Research Group of Personalized Diet, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, Republic of Korea.
3Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
4Digital Omics Research Center, Korea Basic Science Institute, Cheongju, Republic of Korea.
5Critical Diseases Diagnostics Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
6Gwangju Center, Korea Basic Science Institute (KBSI), Gwangju, Republic of Korea.
7These authors contributed equally: Moon-Gi Hong, Eun-Ji Song, Hye Jin Yoon.
Corresponding authors
Correspondence to Sang-Nam Lee, Kwang Soon Kim or Young-Do Nam.
Abstract
Akkermansia muciniphila, a promising candidate for next-generation probiotics, exhibits significant genomic diversity, classified into several distinct clades (AmI to AmIV). Notably, a single Akkermansia clade tends to predominate within individual hosts, with co-occurrence of different clades being rare. The mechanisms driving such clade-specific exclusion remain unclear. Here, we show that extracellular vesicles (EVs) derived from AmII clade inhibit the growth of clade I (AmI), conferring a competitive advantage to AmII. Moreover, we observe clade-specific immunoglobulin A (IgA) responses, where AmII clade-specific IgAs, induced by EVs from AmII, facilitate niche occupancy and competitive exclusion of AmI. These findings provide insights into the competitive dynamics of A. muciniphila clades and suggest that future personalized microbiome interventions could be optimized by considering the clade composition of A. muciniphila in individual hosts.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-20)
- 국내 연구진
- 생명과학 > 미생물학
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