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J. Control. Release, Mar 11 2025, S0168-3659(25)00242-1 | https://doi.org/10.1016/j.jconrel.2025.113625
Curcumin-PLGA NPs coated with targeting biomimetic personalized stem cell membranes for osteoarthritis therapy
Sunjun Lee, Bowon Kim, Min-Ju Lee, Deogil Kim, Sunghyun Park, Jinsik Kim, Yoshie Arai, Soo-Hong Lee
Department of Biomedical Engineering, Dongguk University-Seoul, 04620 Seoul, South Korea
Corresponding authors: Yoshie Arai, Soo-Hong Lee
Department of Biomedical Engineering, Dongguk University-Seoul, 04620 Seoul, South Korea
Corresponding authors: Yoshie Arai, Soo-Hong Lee
Abstract
Traditional drug delivery systems for OA treatments face limitations due to rapid clearance within the joint and low biocompatibility. Moreover, the inflammation associated with OA exacerbates tissue damage and delays the regenerative capacity of therapeutics. To overcome these limitations, an OA-specific drug delivery system designated dCOL2-CM-Cur-PNPs is developed herein to target OA cartilage for anti-inflammatory and cartilage regeneration purposes. This system is constructed using cell membranes obtained from induced pluripotent stem cell -derived mesenchymal stem cells (iMSC-CMs), poly(D,l-lactide-co-glycolide) (PLGA) nanoparticles loaded with the well-known anti-inflammatory and cartilage-regenerating agent curcumin (Cur-PNPs), and damaged type II collagen (dCOL2)-targeting phospholipids. Coating the Cur-PNPs with iMSC-CMs enhances the sustained release of curcumin and improves its cellular uptake by OA-induced chondrocytes. The dCOL2-CM-Cur-PNPs restores the chondrogenic properties of the OA-induced chondrocytes, inhibit the pro-inflammatory function of M1 macrophages, and promote the anti-inflammatory function of M2 macrophages. The dCOL2-targeting phospholipids integrated on the surface of the iMSC-CMs facilitate specific binding to OA cartilage, as validated by in-vitro and in-vivo experiments. Additionally, the dCOL2-CM-Cur-PNPs alleviate OA progression in a DMM rat model. This drug delivery system based on iMSC-CMs modified with dCOL2-targeting phospholipids demonstrates significant potential as a next-generation platform for promoting cartilage regeneration through OA-specific therapy.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-18)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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