한빛사
>
한빛사논문
한빛사논문
- 조회202
Annu. Rev. Immunol., Mar 14 2025, | https://doi.org/10.1146/annurev-immunol-082423-035904
Catch Bonds in Immunology
Hyun-Kyu Choi1,2,3 and Cheng Zhu1,2,4
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
2Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, USA
3Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea
4George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
Corresponding authors: Hyun-Kyu Choi, Cheng Zhu
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
2Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, USA
3Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea
4George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
Corresponding authors: Hyun-Kyu Choi, Cheng Zhu
Abstract
Catch bonds are molecular bonds that last longer under force than slip bonds, which become shorter-lived under force. Although catch bonds were initially discovered in studies of leukocyte and bacterial adhesions two decades ago, they have since been found in many other contexts, including platelet binding to blood vessel walls during clotting, structural support within the cell and between cells, force transmission in the cell's machineries for motility and mechanotransduction, viral infection of host cells, and immunoreceptor mechanosensing. Catch bonds are strengthened by increasing force, which induces structural changes in one or both interacting molecules either locally or allosterically to enable additional contacts at their binding interface, thus lengthening bond lifetimes. They can be modeled by the kinetics of a system escaping from the energy well(s) of the bound state(s) over the energy barrier(s) to the free state by traversing along the dissociation path(s) across a hilly energy landscape modulated by force. Catch bond studies are important for understanding the mechanics of biological systems and developing treatment strategies for infectious diseases, immune disorders, cancer, and other ailments.
논문정보
- Review Paper
- 2025년 03월 (BRIC 등록일 2025-03-17)
- 국내(교신)+국외 연구진
- 생명과학 > 면역학
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
