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Nat. Commun., Published: 15 March 2025 | https://doi.org/10.1038/s41467-025-57716-7
Optically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles
Haeun Kang1,19, Subin Yu1,2,19, Ryeong Myeong Kim3,19, Youngbi Kim4, Sang Chul Shin5, Dohyub Jang6, Jeong Hyun Han3, Sugyeong Hong7, Eunice EunKyeong Kim8, Sun Hee Kim7,9, Dong June Ahn6,10, Jeong Woo Han3, Sehoon Kim10,11, Ki Tae Nam3, Luke P. Lee2,12,13,14 & Dong Ha Kim1,15,16,17,18
1Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea.
2Harvard Medical School, Harvard University; Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
3Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.
4Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea.
5Technological Convergence Center, Research Resources Division, Korea Institute of Science and Technology, Seongbuk-gu, Seoul, Republic of Korea.
6Department of Biomicrosystem Technology, Korea University, Seoul, Republic of Korea.
7Western Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea.
8Biomedical Research Institute, Korea Institute of Science and Technology, Hwarang 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.
9Department of Chemistry, Chung-Ang University, Seoul 06974, Republic of Korea.
10KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.
11Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, 5 Hwarang-ro 14-Gil, Seongbukgu, Seoul, Republic of Korea.
12Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
13Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, USA.
14Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea.
15College of Medicine, Ewha Womans University, Gangseo-gu, Seoul, Republic of Korea.
16Graduate Program in Innovative Biomaterials Convergence, 52 Ewhayeodae-gil, Seodaemun-gu, Ewha Womans University, Seoul, Republic of Korea.
17Basic Sciences Research Institute (Priority Research Institute), Ewha Womans University, Seoul, Republic of Korea.
18Nanobio·Energy Materials Center (National Research Facilities and Equipment Center), Ewha Womans University, Seoul, Republic of Korea.
19These authors contributed equally: Haeun Kang, Subin Yu, Ryeong Myeong Kim.
Corresponding authors
Correspondence to Jeong Woo Han, Sehoon Kim, Ki Tae Nam, Luke P. Lee or Dong Ha Kim.
1Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea.
2Harvard Medical School, Harvard University; Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
3Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.
4Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea.
5Technological Convergence Center, Research Resources Division, Korea Institute of Science and Technology, Seongbuk-gu, Seoul, Republic of Korea.
6Department of Biomicrosystem Technology, Korea University, Seoul, Republic of Korea.
7Western Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea.
8Biomedical Research Institute, Korea Institute of Science and Technology, Hwarang 14-gil 5, Seongbuk-gu, Seoul, Republic of Korea.
9Department of Chemistry, Chung-Ang University, Seoul 06974, Republic of Korea.
10KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.
11Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, 5 Hwarang-ro 14-Gil, Seongbukgu, Seoul, Republic of Korea.
12Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
13Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, USA.
14Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea.
15College of Medicine, Ewha Womans University, Gangseo-gu, Seoul, Republic of Korea.
16Graduate Program in Innovative Biomaterials Convergence, 52 Ewhayeodae-gil, Seodaemun-gu, Ewha Womans University, Seoul, Republic of Korea.
17Basic Sciences Research Institute (Priority Research Institute), Ewha Womans University, Seoul, Republic of Korea.
18Nanobio·Energy Materials Center (National Research Facilities and Equipment Center), Ewha Womans University, Seoul, Republic of Korea.
19These authors contributed equally: Haeun Kang, Subin Yu, Ryeong Myeong Kim.
Corresponding authors
Correspondence to Jeong Woo Han, Sehoon Kim, Ki Tae Nam, Luke P. Lee or Dong Ha Kim.
Abstract
Cascade enzymatic reactions in living organisms are fundamental reaction mechanisms in coordinating various complex biochemical processes such as metabolism, signal transduction, and gene regulation. Many studies have attempted to mimic cascade reactions using nanoparticles with enzyme-like activity; however, precisely tuning each reaction within complex networks to enhance the catalytic activity remains challenging. Here, we present enzyme-like chiral plasmonic nanoparticles for optically tunable catalytic cancer therapy. We create chiral plasmonic nanoparticles with glucose oxidase (GOD) and peroxidase (POD) activities, followed by introducing circularly polarized light (CPL). By sequentially activating GOD and POD reactions with right-handed CPL (RC) followed by left-handed CPL (LC), we achieve 1.25- and 1.9-fold enhanced catalytic performance (overall 1.3 times enhancement) compared to non-controlled cascade reactions by creating an optimal acidic environment for the subsequent reaction. Moreover, the D-Au nanoparticle shows a 2-fold higher binding selectivity to D-glucose substrates, attributed to chirality matching. In both cell studies and male mouse models, sequentially irradiated groups (RC followed by LC) exhibit the highest radical generation and the most efficient treatment outcomes compared to the other systems under different irradiation conditions. We believe that our system holds strong potential for medical applications, suggesting a promising platform for catalytic therapy.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-17)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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