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Nat. Commun., Mar 10 2025, 16 (1) | https://doi.org/10.1038/s41467-025-57701-0
The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice
Jong-Hyun Kim1, Da-Eun Choi1 & Hee-Sup Shin1,2
1Center for Cognition and Sociality, Institute for Basic Science (IBS), 55 Expo-ro, Yusung-gu, Daejeon 34126, Republic of Korea.
2IBS School, University of Science and Technology, Daejeon 34141, Korea.
Corresponding author
Correspondence to Hee-Sup Shin.
1Center for Cognition and Sociality, Institute for Basic Science (IBS), 55 Expo-ro, Yusung-gu, Daejeon 34126, Republic of Korea.
2IBS School, University of Science and Technology, Daejeon 34141, Korea.
Corresponding author
Correspondence to Hee-Sup Shin.
Abstract
Fear can be induced either directly through self-experience of aversive events or vicariously by observing conspecifics experiencing such events. The locus coeruleus-norepinephrine (LC-NA) system is crucial in fear responses and cognitive processes. We investigated whether the LC-NA system differentially processes these two types of fear, direct and vicarious in male mice. The results highlighted that the right hemisphere LC→anterior cingulate cortex pathway is uniquely crucial for vicarious fear, while the two inputs to the LC-from the bed nucleus of the stria terminalis (BNST) and the central amygdala (CeA)-differentially contribute to fear processing. The BNST plays a more targeted role in vicarious fear, and the CeA has a broader influence on fear in general. This underscores the complexity and specialization within the LC-NA system for fear-processing.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-13)
- 국내 연구진
- 생명과학 > 신경생물학
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