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J. Nanobiotechnol., Published: 12 March 2025 | https://doi.org/10.1186/s12951-025-03235-y
Acid-responsive aggregated carrot-derived nanoantioxidants alleviate oxidative stress and restore osteoblast activity
Jiao Peng1,4, Rongyan Liu1,4, Junyi Xu1,4, Yingjuan Yao1,4, Beibei Li1,4, Dengke Chen1,4, Zhuangpeng Chang1,4, Rui Zhao1,4, Yanlin Feng3*, Ruigang Hou1,4*, Min Lee2* and Xiao Zhang1,4*
1Second Clinical Medical College, School of Pharmacy and Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, People’s Republic of China.
2Division of Advanced Prosthodontics, University of California at Los Angeles, Los Angeles, CA 90095, USA.
3Shanxi Provincial Key Laboratory of Cellular Physiological, Shanxi Medical University, Taiyuan, Shanxi 030001, People’s Republic of China.
4Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, People’s Republic of China.
*Correspondence: Yanlin Feng, Ruigang Hou, Min Lee, Xiao Zhang
1Second Clinical Medical College, School of Pharmacy and Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, People’s Republic of China.
2Division of Advanced Prosthodontics, University of California at Los Angeles, Los Angeles, CA 90095, USA.
3Shanxi Provincial Key Laboratory of Cellular Physiological, Shanxi Medical University, Taiyuan, Shanxi 030001, People’s Republic of China.
4Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, People’s Republic of China.
*Correspondence: Yanlin Feng, Ruigang Hou, Min Lee, Xiao Zhang
Abstract
Background
Excessive generation of reactive oxygen species is a hallmark of the osteoporotic bone microenvironment, which leads to the damage of mitochondrial function and the deactivation of osteoblasts. Fruits and vegetables are rich sources of antioxidants, which play a key role in scavenging free radicals and maintaining the body’s homeostasis.
Results
Herein, we have developed a type of vesicle coming from carrots as nanoantioxidants to counteract oxidative stress and restore the vitality of osteoblasts for reversing osteoporosis. Nanovesicles are derived from carrot juice using a straightforward extrusion method, resulting in stable membrane structures containing various lipids and homologous active phytochemicals. Nanovesicles can maintain stable structures under normal physiological conditions (pH 7.4) and transform into aggregates in response to the acidic extracellular pH of osteoporosis (pH 4.0). As anticipated, nanovesicles can passively target and aggregate to osteoporotic bone, ease oxidative stress, restore mitochondrial function, promote osteoblastogenesis, and reduce bone loss in osteoporotic mice.
Conclusions
This work presents the first demonstration of nanovesicles derived from carrots as novel nanoantioxidants to realize the long-awaited osteogenesis, contributing to the exploration of a brand-new idea for reversing osteoporosis.
Excessive generation of reactive oxygen species is a hallmark of the osteoporotic bone microenvironment, which leads to the damage of mitochondrial function and the deactivation of osteoblasts. Fruits and vegetables are rich sources of antioxidants, which play a key role in scavenging free radicals and maintaining the body’s homeostasis.
Results
Herein, we have developed a type of vesicle coming from carrots as nanoantioxidants to counteract oxidative stress and restore the vitality of osteoblasts for reversing osteoporosis. Nanovesicles are derived from carrot juice using a straightforward extrusion method, resulting in stable membrane structures containing various lipids and homologous active phytochemicals. Nanovesicles can maintain stable structures under normal physiological conditions (pH 7.4) and transform into aggregates in response to the acidic extracellular pH of osteoporosis (pH 4.0). As anticipated, nanovesicles can passively target and aggregate to osteoporotic bone, ease oxidative stress, restore mitochondrial function, promote osteoblastogenesis, and reduce bone loss in osteoporotic mice.
Conclusions
This work presents the first demonstration of nanovesicles derived from carrots as novel nanoantioxidants to realize the long-awaited osteogenesis, contributing to the exploration of a brand-new idea for reversing osteoporosis.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-13)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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