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Adv. Mater., Mar 11 2025, | https://doi.org/10.1002/adma.202419250
3D Soft Liquid Metal Electrodes for High-Resolution and Long-Term Electromyography in Muscle Trauma Assessment
Moohyun Kim 1,2, Eun Je Jeon 3, Won Gi Chung 1,2, Heehun Kim 2,4, Enji Kim 1,2, Sanghoon Lee 1,2, Jae-Hyun Lee 2,4, Seung-Woo Cho 2,3,4, Jang-Ung Park 1,2,4,5
1Department of Materials Science & Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
2Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, 03722, Republic of Korea.
3Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
4Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul, 03722, Republic of Korea.
5Department of Neurosurgery, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
M.K. and E.J.J. contributed equally to this work.
Corresponding Authors: Jae-Hyun Lee, Seung-Woo Cho, Jang-Ung Park
1Department of Materials Science & Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
2Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, 03722, Republic of Korea.
3Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
4Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul, 03722, Republic of Korea.
5Department of Neurosurgery, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
M.K. and E.J.J. contributed equally to this work.
Corresponding Authors: Jae-Hyun Lee, Seung-Woo Cho, Jang-Ung Park
Abstract
Electromyography (EMG) is a widely used diagnostic technique for evaluating the electrical activity of muscles and their controlling nerves. However, conventional surface electrodes with planar structures often suffer from low spatial resolution and suboptimal signal quality. Here, 3D-shaped, substrate-free, soft, and biocompatible liquid metal electrodes (LMe) are presented as a wearable interface for neuromuscular signal recording. These electrodes enable the acquisition of high-quality EMG signals while their intrinsic mechanical softness supports long-term use in clinical settings. In a human pilot study, continuous, high-spatial-resolution EMG monitoring of musculoskeletal activity over 25 days is achieved. Furthermore, in vivo EMG monitoring in mouse models of ischemia and volumetric muscle loss demonstrated the therapeutic effects of extracellular muscle-rehabilitative drugs. This work highlights the potential of LMe for advanced drug screening and long-term clinical diagnostics.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-12)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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