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한빛사논문
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- 조회92
Adv. Colloid Interface Sci., Mar 01 2025, 340 S0001-8686(25)00076-4 | https://doi.org/10.1016/j.cis.2025.103465
Medium-chain fatty acids and monoglycerides: Nanoarchitectonics-based insights into molecular self-assembly, membrane interactions, and applications
Bo Kyeong Yoon a, Joshua A. Jackman b
aSchool of Biomedical Engineering, Chonnam National University, Yeosu, Republic of Korea
bSchool of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon, Republic of Korea
Corresponding author : Joshua A. Jackman
aSchool of Biomedical Engineering, Chonnam National University, Yeosu, Republic of Korea
bSchool of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon, Republic of Korea
Corresponding author : Joshua A. Jackman
Abstract
Medium-chain fatty acids (FAs) and monoglycerides (MGs) with saturated 6- to 12‑carbon long tails are single-chain lipid amphiphiles that demonstrate significant application merits. Key examples include their antimicrobial activity against antibiotic-resistant bacteria and emerging viral threats as well as innovations in oral pharmaceutics and biorenewable chemical production. These diverse functionalities are enabled by FA and MG self-assembly and their interactions with biological membranes. However, an integrated viewpoint connecting interfacial science principles to the broader application scope remains lacking. The objective of this review is to cover the latest progress in medium-chain FA and MG research and to build connections between molecular self-assembly, membrane interactions, and applications. By taking a bottom-up nanoarchitectonics perspective, we first examine molecular self-assembly principles, including ionization properties and formation of colloidal nanostructures such as micelles and vesicles. We then discuss membrane interaction concepts and experimental findings that illustrate how medium-chain FAs and MGs distinctly interact with phospholipid membranes. Based on this foundation, we highlight cutting-edge applications in medicine, agriculture, drug delivery, and sustainability, linking these advances to interfacial science concepts. In addition, we emphasize the growing convergence of experimental, theoretical, and computational approaches and offer a forward-looking perspective on future research needs and application opportunities.
논문정보
- Review Paper
- 2025년 03월 (BRIC 등록일 2025-03-10)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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