이승희 (기초과학연구원, KAIST) | 한빛사논문 > 한빛사

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기초과학연구원, KAIST

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Nat. Commun., 07 March 2025 | https://doi.org/10.1038/s41467-025-57347-y Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions

Ilsong Choi¹& Seung-Hee Lee^1,2

¹Center for Synaptic Brain Dysfunctions, IBS, Daejeon 34141, Republic of Korea.
²Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

Corresponding author
Correspondence to Seung-Hee Lee.

Abstract

Decision-making in mammals fundamentally relies on integrating multiple sensory inputs, with conflicting information resolved flexibly based on a dominant sensory modality. However, the neural mechanisms underlying state-dependent changes in sensory dominance remain poorly understood. Our study demonstrates that locomotion in mice shifts auditory-dominant decisions toward visual dominance during audiovisual conflicts. Using circuit-specific calcium imaging and optogenetic manipulations, we found that weakened visual representation in the posterior parietal cortex (PPC) leads to auditory-dominant decisions in stationary mice. Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (ACPPC). This shift is mediated by secondary motor cortical neurons projecting to the auditory cortex (M2AC), which specifically inhibit ACPPC neurons without affecting auditory cortical projections to the striatum (ACSTR). Our findings reveal the neural circuit mechanisms underlying auditory gating to the association cortex depending on locomotion states, providing insights into the state-dependent changes in sensory dominance during multisensory decision-making.

논문정보

형식Research article
게재일2025년 03월 (BRIC 등록일 2025-03-10)
연구진국내 연구진
분야 생명과학 > 신경생물학

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