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ACS Nano, Mar 06 2025, | https://doi.org/10.1021/acsnano.4c18846
Biocompatible Neuromorphic Device Array Based on Naturally Sourced Mucin for Implantable Bioelectronics
Kunho Moon 1, Sung Min Rho 1, Byulhana Kim 2,3, Kyungmoon Kwak 1, Beom Soo Kim 1, Dong Hyun Choi 1, Byung Ha Kang 4, Justin J Chung 2,5,6, Hyun Jae Kim 1
1School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2Department of Transdisciplinary Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
3Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
5Innovative Medical Technology Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
6Department of Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Corresponding Author: Hyun Jae Kim
1School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2Department of Transdisciplinary Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
3Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
5Innovative Medical Technology Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
6Department of Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Corresponding Author: Hyun Jae Kim
Abstract
Although the demand for intelligent implantable bioelectronics is steadily increasing, their progress is hindered by the limited availability of materials with sufficient biocompatibility for implantation. Herein, we propose a neuromorphic device with human brain-inspired biomimetic functionality utilizing naturally sourced mucin as the active layer material. The mucin-based neuromorphic memristor (MNM) array successfully mimics key synaptic behaviors uniformly, including a paired-pulse facilitation index of 122.65%, transition from short-term to long-term memory, long-term potentiation, and long-term depression. In addition to the effect of the defect-rich mucin active layer, these behaviors are enhanced by the presence of a MgOx interfacial layer formed at its interface with the Mg top electrode. The cell cytotoxicity test results demonstrate the superior biocompatibility of the MNM array, which shows a relative cell viability of 108.46% after 72 h of cell culture. Moreover, the artificial neural network simulation demonstrates a recognition rate of 89.93% after 125 training epochs, which suggests that naturally sourced materials, including mucin, can be used in implantable bioelectronics for advanced medical healthcare applications.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-11)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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