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조신일Shinil Cho
연세대학교
Bioact. Mater., Available online 19 February 2025 | https://doi.org/10.1016/j.bioactmat.2025.02.006
Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems
Ju Young Lee a,1, Taemin Kim a,1, Shinil Cho a,1, Jiho Shin b, Woon-Hong Yeo c,d,e,f, Tae Soo Kim b, Ki Jun Yu a,g,h
aFunctional Bio-integrated Electronics and Energy Management Laboratory, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemungu, 03722, Seoul, Republic of Korea
bDepartment of Chemical Engineering, Texas A&M University, College Station, TX, 77843, USA
cGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA
dWearable Intelligent Systems and Healthcare Center, Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, 30332, USA
eWallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University School of Medicine, Atlanta, GA, 30332, USA
fParker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA
gYU-KIST Institute, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemungu, 03722, Seoul, Republic of Korea
hThe Biotech Center, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, 37673, Pohang, Gyeongbuk, Republic of Korea
1These authors contributed equally to this work.
Corresponding authors: Woon-Hong Yeo, Tae Soo Kim, Ki Jun Yu
aFunctional Bio-integrated Electronics and Energy Management Laboratory, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemungu, 03722, Seoul, Republic of Korea
bDepartment of Chemical Engineering, Texas A&M University, College Station, TX, 77843, USA
cGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA
dWearable Intelligent Systems and Healthcare Center, Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, 30332, USA
eWallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University School of Medicine, Atlanta, GA, 30332, USA
fParker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA
gYU-KIST Institute, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemungu, 03722, Seoul, Republic of Korea
hThe Biotech Center, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, 37673, Pohang, Gyeongbuk, Republic of Korea
1These authors contributed equally to this work.
Corresponding authors: Woon-Hong Yeo, Tae Soo Kim, Ki Jun Yu
Abstract
Optogenetics enables precise, cell-specific control of neural activity, surpassing traditional electrical stimulation methods that indiscriminately activate nearby cells, making it crucial for rehabilitation, neurological disorder treatment, and understanding neural circuits. Among light sources for delivering light to genetically modified cells, bio-implants integrated with Light Emitting Diodes (LEDs) have recently been the focus of extensive research due to their advantage of enabling local photogeneration. Unlike laser-based systems, which require tethered setups that hinder behavioral experiments, μ-LED-based devices allow for wireless operation, facilitating more natural movement in subjects. Furthermore, μ-LED arrays can be designed with higher spatial resolution compared to waveguide-coupled external light sources, enabling more precise control over neural activity. This paper presents design rules for implantable flexible optogenetic devices based on μ-LED, tailored to the unique anatomical and functional requirements of various regions of the nervous system. Integration of recent advancements in devices with μ-LEDs (e.g. wireless systems, optofluidic systems, multifunctionality, and closed-loop systems) enhances behavioral experiments and deepens understanding of complex neural functions in the brain, spinal cord, autonomic nervous system, and somatic nervous system. The combination of optogenetics with advanced bio-implantable devices offers promising avenues in medical science, providing more effective tools for neuromodulation research and clinical applications.
논문정보
- Review Paper
- 2025년 02월 (BRIC 등록일 2025-03-07)
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