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- 조회49
Biomaterials, Available online 4 March 2025, 123232 | https://doi.org/10.1016/j.biomaterials.2025.123232
Enhanced stem cell-mediated therapeutic immune modulation with zinc oxide nanoparticles in liver regenerative therapy
Naeun Park a,b,1, Kyoung Sub Kim a,b,1, Sanghee Lee c, Jang Ho Choi a,b, Kun Na a,b
aDepartment of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, Republic of Korea
bDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, Republic of Korea
cDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA
1These authors contributed equally to this work.
Corresponding author: Prof Kun Na
aDepartment of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, Republic of Korea
bDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, Republic of Korea
cDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA
1These authors contributed equally to this work.
Corresponding author: Prof Kun Na
Abstract
Liver regenerative therapy is critical for severe liver damage, including acute liver failure, fibrosis, post-cancer resection recovery, and autoimmune liver diseases, where restoration of liver tissues is essential. Stem cell-based therapies hold significant promise in liver regeneration by modulating immune responses to create a favorable healing microenvironment. However, their clinical efficacy has been limited by challenges such as poor cell engraftment and survival within the hostile injury site. To address these limitations, we developed a zinc oxide-derived nanoparticle (PZnONP) that enhances stem cell proliferation and activation by releasing bioactive Zn2+ and reactive oxygen species (ROS). Functionalized PZnONP exhibits pH-responsive behavior and improved dispersibility, enabling a lysosome-specific and sustained release of Zn2+ and ROS. Stem cells labeled with PZnONP (ZnBA) demonstrated anti-inflammatory properties, with paracrine effects influencing macrophages and damaged hepatocytes. In murine models of acute and fibrotic liver injury, it effectively migrated to the liver through stem cell homing effects and promoted anti-inflammatory responses by modulating Treg and Th17 cell polarization, as well as M2 and M1 macrophage balance, while reducing collagen synthesis. This study underscores the potential of integrating stem cell-based therapy with nanomedicine to improve regenerative outcomes in liver disease treatment.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-06)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
관련 보도자료
간 섬유화 치료를 위한 산화아연 나노입자 봉입 줄기세포 개발
가톨릭대학교 바이오메디컬화학공학과 나건 교수 연구팀이 손상된 간의 회복을 돕는 줄기세포 치료에 산화아연 나노입자를 융합해 줄기세포의 치료 효과를 획기적으로 높여 난치성 간 질환 치료의 새로운 가능성을 제시했다. 가톨릭대 바이오메디컬화학공학과 나건 교수(교신저자), 생명공학과 박나은 박사(공동 제1저자), 바이오메디컬화학공학과 김경섭 교수(공동 제1저자)는 ‘줄기세포 기반 간 재생치료에서 산화아연 나노입자를 이용한 면역조절 기능 향상 기술’을 개발했다. 이번 연구 결과는 생체재료 분야 유명 국제학술지인 ‘Biomaterials (IF=12.8)’에 온라인 게재됐다.
- Bio통신원
- 2025. 04. 21
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