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한빛사논문
한빛사논문
- 조회28
Biomaterials, Available online 4 March 2025, 123235 | https://doi.org/10.1016/j.biomaterials.2025.123235
Reprogrammed glycolysis-induced augmentation of NIR-II excited photodynamic/photothermal therapy
Chunbai Xiang a,d+, Qihang Ding c+, Ting Jiang a,b+, Yu Liu a, Chao Li a, Xing Yang a, Jia Jia a, Jingjing Xiang e, Yue Wang a, Hui Zhou f, Zhiyun Lu d, Ping Gong a,b, Jong Seung Kim c
aGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
bUniversity of Chinese Academy of Sciences, Beijing 100049, China
cDepartment of Chemistry, Korea University, Seoul 02841, Korea
dKey Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University Cheng du 610064 China
eMarshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China
fState Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China
Corresponding authors: Hui Zhou, Zhiyun Lu, Ping Gong, Jong Seung Kim
aGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
bUniversity of Chinese Academy of Sciences, Beijing 100049, China
cDepartment of Chemistry, Korea University, Seoul 02841, Korea
dKey Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University Cheng du 610064 China
eMarshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China
fState Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China
Corresponding authors: Hui Zhou, Zhiyun Lu, Ping Gong, Jong Seung Kim
Abstract
Small molecule-based multifunctional optical diagnostic materials have garnered considerable interest due to their highly customizable structures, tunable excited-state properties, and remarkable biocompatibility. We herein report the synthesis of a multifaceted photosensitizer, PPQ-CTPA, which exhibits exceptional efficacy in generating Type I reactive oxygen species (ROS) and thermal energy under near-infrared-II (NIR-II, >1000 nm) laser excitation at 1064 nm, thereby combining photodynamic therapy (PDT) and photothermal therapy (PTT) functionalities. To enhance therapeutic efficacy, we engineered lonidamine (LND) by conjugating it with triphenylphosphonium (TPP) cations, producing LND-TPP. This compound inhibits mitochondrial glycolysis and downregulates heat shock protein 90 (HSP 90) levels in a breast cancer mouse model, potentiating both PDT and PTT. For in vivo applications, PPQ-CTPA and LND-TPP are encapsulated within the amphiphilic polymer DSPE-SS-PEG to obtain PPQ-CTPAL NPs. In breast cancer cell lines, PPQ-CTPAL NPs are decomposed by cellular GSH, simultaneously releasing the dual-functioning photosensitizer PPQ-CTPL and the mitochondria-disrupting agent LND-TPP. Upon 1064 nm laser irradiation, we found that tumor growth in breast cancer mice is effectively restrained by PPQ-CTPAL NPs. This work highlights the synergistic integration of PDT, PTT, and chemotherapy facilitated by NIR-II fluorescence, photoacoustic, and photothermal imaging under 1064 nm irradiation, underscoring the clinical potential of multifunctional phototherapeutic agents.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-19)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오·의료융합 기타
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