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- 조회65
이혜리Hyeri Lee
경희대학교
J. Cachexia Sarcopenia Muscle, 05 March 2025 | https://doi.org/10.1002/jcsm.13772
Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta-Analyses
Masoud Rahmati1,2,3,4, Hyeri Lee5, Hayeon Lee5, Jaeyu Park5, Djandan Tadum Arthur Vithran6, Yusheng Li6, Abdolreza Kazemi4, Laurent Boyer1,2, Guillaume Fond1,2, Lee Smith7, Nicola Veronese8, Pinar Soysal9, Elena Dragioti10,11, Samuele Cortese12,13,14,15,16, Jiseung Kang17,18,19, Dong Keon Yon5,20, Marco Solmi21,22,23,24
1CEReSS-Health Service Research and Quality of Life Center, Assistance Publique-Hopitaux de Marseille, Aix-Marseille University, Marseille, France
2CRSMP, Center for Mental Health and Psychiatry Research – PACA, Marseille, France
3Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
4Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran
5Center for Digital Health, Medical Science Research Institute, KyungHee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
6Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China
7Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
8Saint Camillus International University of Health Sciences, Rome, Italy
9Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
10Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
11Research Laboratory Psychology of Patients, Families & Health Professionals, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece
12Developmental EPI (Evidence synthesis, Prediction, Implementation) Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK
13Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK
14Hampshire and Isle of Wight Healthcare NHS Foundation Trust, Southampton, UK
15Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York, New York, USA
16DiMePRe-J-Department of Precision and Regenerative Medicine-Jonic Area, University of Bari “Aldo Moro”, Bari, Italy
17Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
18Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA
19School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea
20Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea
21On Track: The Champlain First Episode Psychosis Program, Department of Mental Health, The Ottawa Hospital, Ottawa, Ontario, Canada
22Clinical Epidemiology Program, Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Ontario, Canada
23Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany
24Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
1CEReSS-Health Service Research and Quality of Life Center, Assistance Publique-Hopitaux de Marseille, Aix-Marseille University, Marseille, France
2CRSMP, Center for Mental Health and Psychiatry Research – PACA, Marseille, France
3Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
4Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran
5Center for Digital Health, Medical Science Research Institute, KyungHee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
6Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China
7Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
8Saint Camillus International University of Health Sciences, Rome, Italy
9Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
10Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
11Research Laboratory Psychology of Patients, Families & Health Professionals, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece
12Developmental EPI (Evidence synthesis, Prediction, Implementation) Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK
13Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK
14Hampshire and Isle of Wight Healthcare NHS Foundation Trust, Southampton, UK
15Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York, New York, USA
16DiMePRe-J-Department of Precision and Regenerative Medicine-Jonic Area, University of Bari “Aldo Moro”, Bari, Italy
17Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
18Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA
19School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea
20Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea
21On Track: The Champlain First Episode Psychosis Program, Department of Mental Health, The Ottawa Hospital, Ottawa, Ontario, Canada
22Clinical Epidemiology Program, Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, Ontario, Canada
23Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany
24Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
Masoud Rahmati, Hyeri Lee and Djandan Tadum Arthur Vithran are joint first authors.
Correspondence: Masoud Rahmati, Dong Keon Yon
Correspondence: Masoud Rahmati, Dong Keon Yon
Abstract
Background: Numerous studies support the association of exercise training, physical activity (PA) and sedentary behaviour (SB) with both mortality and morbidity outcomes. The results across studies have been inconsistent, and no umbrella reviews have yet been conducted on this topic.
Methods: We conducted an umbrella review of meta-analyses of observational studies by screening articles in PubMed/MEDLINE, EMBASE and Web of Science databases from inception to 30 April 2024. Quality appraisal of each included meta-analysis was done using the AMSTAR 2 tool, with evidence certainty evaluated based on statistical significance, study size, heterogeneity, small-study effects, prediction intervals (PI) and potential biases.
Results: Frothy-eight meta-analyses were included (AMSTAR 2 ratings: high 25, moderate 10, low 2 and critically low 11). No evidence was highly suggestive or convincing. Suggestive evidence linked any PA and SB to lower and higher risks of all-cause, cardiovascular and cancer mortality. Suggestive evidence indicated a significant association between self-reported and device-measured total PA (equivalent odds ratio [eOR] 0.78 [0.70-0.86] and eHR = 0.50 [0.38-0.65], respectively), self-reported leisure time PA (eHR = 0.73 [0.66-0.80]), device-measured daily steps (eHR = 0.44 [0.35-0.56]) and aerobic plus resistance training (eHR = 0.60 [0.56-0.64]) with lower all-cause mortality. Weak evidence supported links between self-reported and device-measured SB and higher mortality (eHR = 1.3 [1.22-1.38] and eHR = 2.16 [1.09-4.28], respectively). Suggestive evidence was noted for the association between self-reported leisure time PA (eHR = 0.74 [0.69-0.80]) and resistance training (eHR = 0.82 [0.81-0.84]) with cardiovascular mortality. Suggestive evidence was also found for the association between self-reported leisure time PA (eHR = 0.87 [0.83-0.91]) with cancer mortality. Associations between self-reported running time and mortality from all causes, cardiovascular diseases (CVD) and cancer did not reach statistical significance nor did the association between low skeletal muscle mass and all-cause mortality. Meta-regression analyses showed that physical activity reduces mortality risk, with age reducing the protective effects against all-cause, CVD and cancer mortality. We also found that combined exercise training (aerobic plus resistance) most effectively reduces all-cause and CVD mortality.
Conclusions: Converging evidence supports that physical activity and sedentary behaviour are associated with lower and higher rates of all-cause, cardiovascular and cancer mortality. More high-quality prospective studies are needed for a better understanding of the associations between running time and also TV-viewing time and health-related outcomes.
Methods: We conducted an umbrella review of meta-analyses of observational studies by screening articles in PubMed/MEDLINE, EMBASE and Web of Science databases from inception to 30 April 2024. Quality appraisal of each included meta-analysis was done using the AMSTAR 2 tool, with evidence certainty evaluated based on statistical significance, study size, heterogeneity, small-study effects, prediction intervals (PI) and potential biases.
Results: Frothy-eight meta-analyses were included (AMSTAR 2 ratings: high 25, moderate 10, low 2 and critically low 11). No evidence was highly suggestive or convincing. Suggestive evidence linked any PA and SB to lower and higher risks of all-cause, cardiovascular and cancer mortality. Suggestive evidence indicated a significant association between self-reported and device-measured total PA (equivalent odds ratio [eOR] 0.78 [0.70-0.86] and eHR = 0.50 [0.38-0.65], respectively), self-reported leisure time PA (eHR = 0.73 [0.66-0.80]), device-measured daily steps (eHR = 0.44 [0.35-0.56]) and aerobic plus resistance training (eHR = 0.60 [0.56-0.64]) with lower all-cause mortality. Weak evidence supported links between self-reported and device-measured SB and higher mortality (eHR = 1.3 [1.22-1.38] and eHR = 2.16 [1.09-4.28], respectively). Suggestive evidence was noted for the association between self-reported leisure time PA (eHR = 0.74 [0.69-0.80]) and resistance training (eHR = 0.82 [0.81-0.84]) with cardiovascular mortality. Suggestive evidence was also found for the association between self-reported leisure time PA (eHR = 0.87 [0.83-0.91]) with cancer mortality. Associations between self-reported running time and mortality from all causes, cardiovascular diseases (CVD) and cancer did not reach statistical significance nor did the association between low skeletal muscle mass and all-cause mortality. Meta-regression analyses showed that physical activity reduces mortality risk, with age reducing the protective effects against all-cause, CVD and cancer mortality. We also found that combined exercise training (aerobic plus resistance) most effectively reduces all-cause and CVD mortality.
Conclusions: Converging evidence supports that physical activity and sedentary behaviour are associated with lower and higher rates of all-cause, cardiovascular and cancer mortality. More high-quality prospective studies are needed for a better understanding of the associations between running time and also TV-viewing time and health-related outcomes.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-06)
- 국내(교신)+국외 연구진
- 의약학 > 의약학 기타
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