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Sci. China Chem., 2023, 66: 155–163 | https://doi.org/10.1007/s11426-022-1440-2
Construction of a 980 nm laser-activated Pt (II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization
Yuling Xu 1†, Chonglu Li 1†, Jusung An 2†, Xin Ma 3, Jingfang Yang 1, Lishi Luo 4, Yun Deng 5, Jong Seung Kim 2* & Yao Sun 1*
1Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China
2Department of Chemistry, Korea University, Seoul 02841, Republic of Korea
3Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, China
4State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China
5Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan 430056, China
2Department of Chemistry, Korea University, Seoul 02841, Republic of Korea
3Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, China
4State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China
5Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan 430056, China
†These authors contributed equally
*Corresponding authors: correspondence to Jong Seung Kim
*Corresponding authors: correspondence to Jong Seung Kim
Abstract
Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy, their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult. We therefore synthesized a novel Pt(II) metallacycle (Pt1110) that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue. We found that Pt1110 significantly improved photothermal conversion (95% improvement) and 1O2 generation (ΦΔ 75% increase) compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation (0.72 W/cm2). In addition, Pt1110 has little to no toxicity to cells. After incorporated into liposome, Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation, which was accurately observed by NIR-II fluorescence imaging. This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2025-03-06)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
- 60회 이상 인용된 논문
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