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Trends Genet., Mar 04 2025, S0168-9525(25)00027-7 | https://doi.org/10.1016/j.tig.2025.02.001
Strategies for studying sex differences in brain aging
Victor A. Ansere 1,9, Seung-Soo Kim 2,9, Francesca Marino 3,9, Katherine Morillo 4,9, Dena B. Dubal 3, Coleen T. Murphy 4,5, Yousin Suh 2,6, Bérénice A. Benayoun 1,7,8
1Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
2Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA
3Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA
4Department of Molecular Biology, Princeton University, Princeton, NJ, USA
5LSI Genomics, Princeton University, Princeton, NJ, USA
6Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA
7Molecular and Computational Biology Department, USC Dornsife College of Letters, Arts and Sciences, Los Angeles, CA 90089, USA
8Biochemistry and Molecular Medicine Department, USC Keck School of Medicine, Los Angeles, CA 90089, USA
9These authors contributed equally.
Correspondence: Dena B. Dubal, Coleen T. Murphy, Yousin Suh, Bérénice A. Benayoun
1Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
2Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA
3Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA
4Department of Molecular Biology, Princeton University, Princeton, NJ, USA
5LSI Genomics, Princeton University, Princeton, NJ, USA
6Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA
7Molecular and Computational Biology Department, USC Dornsife College of Letters, Arts and Sciences, Los Angeles, CA 90089, USA
8Biochemistry and Molecular Medicine Department, USC Keck School of Medicine, Los Angeles, CA 90089, USA
9These authors contributed equally.
Correspondence: Dena B. Dubal, Coleen T. Murphy, Yousin Suh, Bérénice A. Benayoun
Abstract
Studying sex effects and their underlying mechanisms is of major relevance to understanding brain health. Despite growing interests, experimentally studying sex differences, particularly in the context of aging, remains challenging. Since sex chromosomal content influences gonadal development, separating the effects of gonadal hormones and chromosomal factors requires specific model systems. Here, we highlight rodent and tractable models for examining sex dimorphism in brain and cognitive aging. In addition, we discuss multi-omic and bioinformatic approaches that yield biological insights from animal and human studies. This review provides a comprehensive overview of the diverse toolkit now available to advance our understanding of sex differences in brain aging.
논문정보
- Review Paper
- 2025년 03월 (BRIC 등록일 2025-03-06)
- 국외 연구진
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