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Nat. Commun., Published: 04 March 2025 | https://doi.org/10.1038/s41467-025-57041-z
Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice
Hyoung-Gon Ko1,2, Hyunsu Jung3,4,9, Seunghyo Han1,9, Dong Il Choi4,9, Chiwoo Lee4,9, Ja Eun Choi4, Jihae Oh4, Chuljung Kwak3, Dae Hee Han3, Jun-Nyeong Kim1, Sanghyun Ye4, Jiah Lee4, Jaehyun Lee4, Kyungmin Lee5, Jae-Hyung Lee6, Min Zhuo7,8 & Bong-Kiun Kaang3,4
1Department of Anatomy and Neurobiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, 2177 Dalgubeoldaero, Daegu, South Korea.
2Department of Oral Anatomy and Developmental Biology, Kyung Hee University College of Dentistry, Seoul, South Korea.
3Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 34126, South Korea.
4Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Seoul, South Korea.
5Laboratory for Behavioral Neural Circuitry and Physiology, Department of Anatomy, Brain Science and Engineering Institute, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Daegu, South Korea.
6Department of Oral Microbiology, College of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Seoul, South Korea.
7Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario, Canada.
8International Institute for Brain Research, Qingdao International Academician Park, Qingdao, China.
9These authors contributed equally: Hyunsu Jung, Seunghyo Han, Dong Il Choi, Chiwoo Lee.
Corresponding authors
Correspondence to Hyoung-Gon Ko or Bong-Kiun Kaang.
1Department of Anatomy and Neurobiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, 2177 Dalgubeoldaero, Daegu, South Korea.
2Department of Oral Anatomy and Developmental Biology, Kyung Hee University College of Dentistry, Seoul, South Korea.
3Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 34126, South Korea.
4Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Seoul, South Korea.
5Laboratory for Behavioral Neural Circuitry and Physiology, Department of Anatomy, Brain Science and Engineering Institute, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Daegu, South Korea.
6Department of Oral Microbiology, College of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Seoul, South Korea.
7Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario, Canada.
8International Institute for Brain Research, Qingdao International Academician Park, Qingdao, China.
9These authors contributed equally: Hyunsu Jung, Seunghyo Han, Dong Il Choi, Chiwoo Lee.
Corresponding authors
Correspondence to Hyoung-Gon Ko or Bong-Kiun Kaang.
Abstract
Pain and itch are aversive sensations with distinct qualities, processed in overlapping pathways and brain regions, including the anterior cingulate cortex (ACC), which is critical for their affective dimensions. However, the cellular mechanisms underlying their processing in the ACC remain unclear. Here, we identify modality-specific neuronal populations in layer II/III of the ACC in mice involved in pain and itch processing. Using a synapse labeling tool, we show that pain- and itch-related neurons selectively receive synaptic inputs from mediodorsal thalamic neurons activated by pain and itch stimuli, respectively. Chemogenetic inhibition of these neurons reduced pruriception or nociception without affecting the opposite modality. Conversely, activation of these neurons did not enhance stimulus-specific responses but commonly increased freezing-like behavior. These findings reveal that the processing of itch and pain information in the ACC involves activity-dependent and modality-specific neuronal populations, and that pain and itch are processed by functionally distinct ACC neuronal subsets.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2025-03-05)
- 국내 연구진
- 생명과학 > 신경생물학
관련 보도자료
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- Bio통신원
- 2025. 03. 05
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