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이다견Dakyeon Lee
부산대학교
Carbon, Available online 24 February 2025 | https://doi.org/10.1016/j.carbon.2025.120127
Zebrafish embryo toxicity to ssDNA-wrapped carbon nanotube dispersion: From whole-body to single-cell resolution
Hyeon Mi Sung a,b,1, Eun Jung Kwon c,1, Dakyeon Lee d,1, Yunseo Jung d, Yun Hak Kim e,f, Chang-Kyu Oh b,g, Sanghwa Jeong d
aDepartment of Convergence Medical Sciences, School of Medicine, Pusan National University, Yangsan, 50612, South Korea
bInstitute for Future Earth, Pusan National University, Busan, 46241, South Korea
cMedical Research Institute, Pusan National University, Yangsan, 50612, South Korea
dSchool of Biomedical Convergence Engineering, Pusan National University, Yangsan, 50612, South Korea
eDepartment of Biomedical Informatics, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan, 50612, South Korea
fDepartment of Anatomy, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan, 50612, South Korea
gDepartment of Biochemistry, School of Medicine, Pusan National University, Yangsan, 50612, South Korea
1These authors contributed equally to this work.
Corresponding authors: Yun Hak Kim, Chang-Kyu Oh, Sanghwa Jeong
aDepartment of Convergence Medical Sciences, School of Medicine, Pusan National University, Yangsan, 50612, South Korea
bInstitute for Future Earth, Pusan National University, Busan, 46241, South Korea
cMedical Research Institute, Pusan National University, Yangsan, 50612, South Korea
dSchool of Biomedical Convergence Engineering, Pusan National University, Yangsan, 50612, South Korea
eDepartment of Biomedical Informatics, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan, 50612, South Korea
fDepartment of Anatomy, School of Medicine, Pusan National University, 49 Busandaehak-ro, Yangsan, 50612, South Korea
gDepartment of Biochemistry, School of Medicine, Pusan National University, Yangsan, 50612, South Korea
1These authors contributed equally to this work.
Corresponding authors: Yun Hak Kim, Chang-Kyu Oh, Sanghwa Jeong
Abstract
Single-walled carbon nanotubes (SWCNTs) possess exceptional mechanical, electrical, and chemical properties, making them highly valuable for applications across various fields. However, concerns about their potential toxicity, particularly in biological contexts, have limited their broader use. In this study, we evaluated the biocompatibility of (GT)6 ssDNA-wrapped SWCNTs using zebrafish embryos as a model organism. Zebrafish embryos were exposed to SWCNT concentrations of 2 mg/L and 10 mg/L, and their development was monitored over 96 h post-fertilization. We observed no significant differences in survival, growth, heart rate, and hatching rates between ssDNA-coated SWCNTs exposed embryos and controls. Additionally, single-cell RNA sequencing revealed no significant changes in gene expression across multiple cell types, further supporting the biocompatibility of ssDNA-coated SWCNTs. This research contributes to the growing body of knowledge regarding SWCNT safety and supports their potential for wider applications in drug delivery, biosensing, and other advanced material fields.
논문정보
- Research article
- 2025년 02월 (BRIC 등록일 2025-03-04)
- 국내 연구진
- 바이오·의료융합 > 바이오·의료융합 기타
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