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- 조회87
신동준Dongjun Shin
인하대학교
Small Methods, Feb 25 2025, | https://doi.org/10.1002/smtd.202402058
Exosome-Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering
Mohit J. Mehta 1,2, Dongjun Shin 1, Hyun Sung Park 1, Jun Su An 1, Seong Il Lim 1, Hyun Jin Kim 1,3,4, Seungpyo Hong 5,6, Jiyoon Bu 1,3,4
1Department of Biological Sciences and Bioengineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, Republic of Korea.
2Adult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
3Department of Biological Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, Republic of Korea.
4Biohybrid Systems Research Center, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, Republic of Korea.
5Pharmaceutical Sciences Division and Wisconsin Center for NanoBioSystems (WisCNano), School of Pharmacy, University of Wisconsin - Madison, 777 Highland Ave, Madison, WI, 53705, USA.
6Yonsei Frontier Lab and Department of Pharmacy, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea.
M.J.M. and D.S. contributed equally to this work.
Corresponding Authors: Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu
1Department of Biological Sciences and Bioengineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, Republic of Korea.
2Adult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
3Department of Biological Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, Republic of Korea.
4Biohybrid Systems Research Center, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, Republic of Korea.
5Pharmaceutical Sciences Division and Wisconsin Center for NanoBioSystems (WisCNano), School of Pharmacy, University of Wisconsin - Madison, 777 Highland Ave, Madison, WI, 53705, USA.
6Yonsei Frontier Lab and Department of Pharmacy, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea.
M.J.M. and D.S. contributed equally to this work.
Corresponding Authors: Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu
Abstract
Exosomes have emerged as versatile biomolecules in gastrointestinal (GI) cancer management, leveraging their inherent cargo-carrying capabilities to overcome the limitations of current diagnostic and therapeutic strategies. This review provides a comprehensive exploration of exosome-based technologies, highlighting their dual roles as diagnostic biomarkers and therapeutic vehicles. On the diagnostic front, this review investigates specific exosomal biomarkers-including miRNAs, lncRNAs, circRNAs, and proteins-emphasizing their roles in tumor biology and their clinical utility, such as diagnostic accuracy, early detection potential, and prognostic significance. Therapeutically, this study examines the sources, purification methodologies, and engineering strategies that enhance the therapeutic efficacy of exosomes in modulating immune responses, overcoming drug resistance, and suppressing metastasis. By providing a comprehensive overview of the field, this review serves as a guideline for researchers and clinicians entering this field, offering novel insights into the potential of exosome-based theranostic systems and delineating future directions to overcome existing challenges.
논문정보
- Review Paper
- 2025년 02월 (BRIC 등록일 2025-02-27)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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