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Duke University School of Medicine, 현 The Rockefeller University & Memorial Sloan Kettering Cancer Center
Nat. Phys., 25 February 2025 | https://doi.org/10.1038/s41567-025-02796-x
Topological interactions drive the first fate decision in the Drosophila embryo
Woonyung Hur1,6, Arghyadip Mukherjee2,6, Luke Hayden1, Ziqi Lu1, Anna Chao1, Noah P. Mitchell3,4, Sebastian J. Streichan3,4, Massimo Vergassola2,5 & Stefano Di Talia1
1Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
2Laboratoire de physique de l’Ecole Normale Superieure, CNRS, PSL Research University, Sorbonne Universite, Paris, France.
3Kavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, CA, USA.
4Department of Physics, University of California, Santa Barbara, Santa Barbara, CA, USA.
5Department of Physics, University of California, San Diego, La Jolla, CA, USA.
6These authors contributed equally: Woonyung Hur, Arghyadip Mukherjee.
Corresponding authors
Correspondence to Arghyadip Mukherjee, Massimo Vergassola or Stefano Di Talia.
1Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
2Laboratoire de physique de l’Ecole Normale Superieure, CNRS, PSL Research University, Sorbonne Universite, Paris, France.
3Kavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, CA, USA.
4Department of Physics, University of California, Santa Barbara, Santa Barbara, CA, USA.
5Department of Physics, University of California, San Diego, La Jolla, CA, USA.
6These authors contributed equally: Woonyung Hur, Arghyadip Mukherjee.
Corresponding authors
Correspondence to Arghyadip Mukherjee, Massimo Vergassola or Stefano Di Talia.
Abstract
During embryogenesis, the first cell fate decision—whether the cell participates in development of the embryo or not—is often linked to the positioning of the nucleus. The cell cycle oscillator and associated cytoskeletal dynamics contribute to the control of nuclear positioning. However, the mechanisms that ensure that the correct number of nuclei move to their appropriate place remain poorly understood. Here we show that the orientation of the mitotic spindle controls the first fate decision, embryonic or yolk cell fate, in Drosophila embryos using light sheet microscopy experiments. Combining computational methods inspired by integral geometry, manipulation of cell cycle genes, and investigation of the relationship between geometry and topology, we show that spindle orientation is controlled by topological interactions with neighbouring nuclei and not by internuclear distance. Leveraging the physics of space-filling systems, we develop a theory for topological dependency in microtubule structures. Our work shows how the topological interplay of microtubule mechanics can ensure robust control of nuclear density and determine cell fate.
논문정보
- Research article
- 2025년 02월 (BRIC 등록일 2025-02-27)
- 국외 연구진
- 생명과학 > 발생생물학
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