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Nat. Commun., Published: 25 February 2025 | https://doi.org/10.1038/s41467-025-57237-3
Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease
Jae-Won Yoon1,10, Kyung Min Kim2,10, Sookyung Cho1,10, Min-Ji Cho1, Seonjun Park3, Daehee Hwang2, Hye Ryun Kim4, Sung Ho Park3, Jae-Ho Cho5, Hyobin Jeong6 & Je-Min Choi1,7,8,9
1Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea.
2Department of Biological Sciences, Seoul National University, Seoul, Korea.
3Department of Biological Sciences, Ulsan National Institute of Science & Technology (UNIST), Ulsan, Republic of Korea.
4Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
5Medical Research Center for Combinatorial Tumor Immunotherapy, Department of Microbiology and Immunology, Chonnam National University Medical School, Hwasun 58128, Korea.
6Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
7Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Republic of Korea.
8Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
9Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Republic of Korea.
10These authors contributed equally: Jae-Won Yoon, Kyung Min Kim, and Sookyung Cho.
Corresponding authors
Correspondence to Hyobin Jeong or Je-Min Choi.
1Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea.
2Department of Biological Sciences, Seoul National University, Seoul, Korea.
3Department of Biological Sciences, Ulsan National Institute of Science & Technology (UNIST), Ulsan, Republic of Korea.
4Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
5Medical Research Center for Combinatorial Tumor Immunotherapy, Department of Microbiology and Immunology, Chonnam National University Medical School, Hwasun 58128, Korea.
6Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
7Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Republic of Korea.
8Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
9Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Republic of Korea.
10These authors contributed equally: Jae-Won Yoon, Kyung Min Kim, and Sookyung Cho.
Corresponding authors
Correspondence to Hyobin Jeong or Je-Min Choi.
Abstract
Naïve CD4 T cells are traditionally viewed as a quiescent, homogeneous, resting population, but emerging evidence reveals their heterogeneity, which can be crucial for understanding disease contexts and therapeutic outcomes. In this study, we identify distinct subpopulations within both murine and human naïve CD4 T cells by single cell-RNA-sequencing (scRNA-seq), particularly focusing on a subpopulation that expresses super-high levels of interleukin-7 receptor (IL-7Rsup-hi), along with CD97, IL-18R, and Ly6C. This subpopulation, absent in the thymus and peripherally induced, exhibits type 1 helper T cell (Th1)-poised characteristics and contributes to the inhibition of cancer progression in B16F10 tumor-bearing mice. In humans, this IL-7Rsup-hi subpopulation expressing CD97 correlates with the responsiveness to anti-PD-1 therapy in cancer patients and the disease state of multiple sclerosis. By elucidating the heterogeneity of naive CD4 T cells and identifying a Th1-poised subpopulation capable of robust type 1 responses, we highlight the importance of this heterogeneity in inflammatory conditions for defining the disease states and predicting drug responsiveness.
논문정보
- Research article
- 2025년 02월 (BRIC 등록일 2025-02-26)
- 국내 연구진
- 생명과학 > 면역학
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