한빛사
>
한빛사논문
한빛사논문
- 조회79
Alzheimers. Dement., Feb 2025, 21 (2) | https://doi.org/10.1002/alz.14606
Moderation of midlife cognitive activity on tau-related cognitive impairment
Kang Ko1,2 Dahyun Yi3 Min Soo Byun1,4 Joon Hyung Jung5 Nayeong Kong6 Gijung Jung4 Hyejin Ahn4 Yoon Young Chang7 Musung Keum4 Jun-Young Lee1,8 Yun-Sang Lee9 Yu Kyeong Kim10 Dong Young Lee1,3,4 for the KBASE Research Group
1 Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
2 Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea
3 Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea
4 Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
5 Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Republic of Korea
6 Department of Psychiatry, Keimyung University Dongsan Hospital, Daegu, Republic of Korea
7 Department of Psychiatry, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea
8 Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea
9 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
10 Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea
Correspondence : Dong Young Lee
1 Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
2 Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea
3 Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea
4 Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
5 Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Republic of Korea
6 Department of Psychiatry, Keimyung University Dongsan Hospital, Daegu, Republic of Korea
7 Department of Psychiatry, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea
8 Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea
9 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
10 Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea
Correspondence : Dong Young Lee
Abstract
Introduction: We investigated the moderating effects of midlife and late-life cognitive activity (CA) on the relationship between tau pathology and both cognition and cognitive decline.
Methods: Eighty-nine non-demented older adults from a Korean cohort underwent comprehensive evaluations, including CA assessments and tau neuroimaging at baseline, and Mini-Mental State Examination (MMSE) at baseline and the 2-year follow-up.
Results: Greater midlife CA was associated with higher MMSE scores in a given amount of tau pathology, whereas higher levels of midlife CA were associated with faster tau-related decline in MMSE scores, particularly in individuals with mild cognitive impairment. Late-life CA did not exhibit any interaction with tau on either MMSE scores or their 2-year change.
Discussion: Greater midlife CA is generally associated with better cognitive performance despite the presence of tau pathology. However, paradoxically, increased midlife CA appears to be linked to a more rapid tau-related cognitive decline in already cognitively impaired individuals.
Highlights: Greater midlife cognitive activity (CA) was generally associated with better cognitive performance in a given amount of tau pathology. Paradoxically, higher levels of midlife CA were related to a more rapid tau-related cognitive decline in already cognitively impaired individuals. Late-life CA did not exhibit any moderation effect on the association between tau and cognitive performance or decline.
Methods: Eighty-nine non-demented older adults from a Korean cohort underwent comprehensive evaluations, including CA assessments and tau neuroimaging at baseline, and Mini-Mental State Examination (MMSE) at baseline and the 2-year follow-up.
Results: Greater midlife CA was associated with higher MMSE scores in a given amount of tau pathology, whereas higher levels of midlife CA were associated with faster tau-related decline in MMSE scores, particularly in individuals with mild cognitive impairment. Late-life CA did not exhibit any interaction with tau on either MMSE scores or their 2-year change.
Discussion: Greater midlife CA is generally associated with better cognitive performance despite the presence of tau pathology. However, paradoxically, increased midlife CA appears to be linked to a more rapid tau-related cognitive decline in already cognitively impaired individuals.
Highlights: Greater midlife cognitive activity (CA) was generally associated with better cognitive performance in a given amount of tau pathology. Paradoxically, higher levels of midlife CA were related to a more rapid tau-related cognitive decline in already cognitively impaired individuals. Late-life CA did not exhibit any moderation effect on the association between tau and cognitive performance or decline.
논문정보
- Research article
- 2025년 02월 (BRIC 등록일 2025-03-13)
- 국내 연구진
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
