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- 조회175
김현주Hyunju Kim
University of Washington
Trends Endocrinol. Metab., Available online 20 February 2025 | https://doi.org/10.1016/j.tem.2025.01.007
Insights from omics research on plant-based diets and cardiometabolic health
Hyunju Kim 1,2, Casey M. Rebholz 3,4,5
1Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA
2Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
4Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
5Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Correspondence: Casey M. Rebholz
1Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA
2Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
4Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
5Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Correspondence: Casey M. Rebholz
Abstract
Plant-based diets emphasize higher intake of plant foods and are low in animal products. Individuals following plant-based diets have a lower risk of chronic conditions; however, the mechanisms underlying these associations are not completely understood. Omics data have opened opportunities to investigate the mechanistic effect of dietary intake on health outcomes. Here, we review omics analyses of plant-based diets in feeding and observational studies, showing that although metabolomics and proteomics identified candidate biomarkers and distinct pathways modifiable by plant-based diets, current evidence from transcriptomics and methylomics is limited. We also argue that future studies should examine how unhealthful plant-based diets are associated with a higher risk of health outcomes and integrate multiple omics data from feeding studies to provide further mechanistic insights.
논문정보
- Review Paper
- 2025년 02월 (BRIC 등록일 2025-02-21)
- 국외 연구진
- 생명과학 > 영양학
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