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Exp. Mol. Med., 18 February 2025 | https://doi.org/10.1038/s12276-025-01404-5
Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice
Si Chen 1, Yu-Bin Lee 2, Mi-Young Song 1, Changjin Lim 2, Hwangeui Cho 2, Hyun Joo Shim 2, Jong-Suk Kim 1, Byung-Hyun Park 3, Jeon-Kyung Kim 2,* and Eun Ju Bae 2,*
1Department of Biochemistry and Molecular Biology, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
2School of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju, Republic of Korea.
3Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejon, Republic of Korea.
2School of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju, Republic of Korea.
3Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejon, Republic of Korea.
*Corresponding authors: correspondence to Jeon-Kyung Kim or Eun Ju Bae
Abstract
Cannabidiol (CBD), a nonpsychoactive compound from Cannabis, has various bioactive functions in humans and animals. Evidence suggests that CBD promotes muscle injury recovery in athletes, but whether and how CBD improves endurance performance remains unclear. Here we investigated the effects of CBD treatment on exercise performance in mice and assessed whether this effect involves the gut microbiome. CBD administration significantly increased treadmill running performance in mice, accompanied by an increase in oxidative myofiber composition. CBD also increased mitochondrial biogenesis and the expression of associated genes such as PGC-1α, phosphorylated CREB and AMPK in muscle tissue. Interestingly, CBD altered the composition of the gut microbiome, and antibiotic treatment reduced the muscle endurance-enhancing effects of CBD and mitochondrial biogenesis. We isolated Bifidobacterium animalis, a microbe increased by CBD administration, and named it KBP-1. Treatment with B. animalis KBP-1 in mice resulted in improved running performance. Whole-genome analysis revealed that B. animalis KBP-1 presented high expression of genes involved in branched-chain amino acid biosynthesis, expression of branched-chain amino acid release pumps and metabolism of lactic acid. In summary, our study identified CBD and B. animalis KBP-1 as potential endurance exercise-promoting agents.
논문정보
- Research article
- 2025년 02월 (BRIC 등록일 2025-02-19)
- 국내 연구진
- 의약학 > 약학
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