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Phytomedicine, Available online 14 February 2025, 156510 | https://doi.org/10.1016/j.phymed.2025.156510
Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study
Seonghui Kim a,b, Min Young Um c, Jin-Kyu Han d, Duhyeon Kim a, Yunjin Choi b, Gibeom Choi a, Chaeyoung Bang e, Youngtaek Oh f, Jang H. Youn f, Suengmok Cho a,b,f
aDepartment of Food Science and Technology, Institute of Food Science, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea
bResearch & Development Center, Nutra-it Inc., 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea
cResearch Division of Food Functionality, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-meyon, Wanju, Jeonbuk 55365, Republic of Korea
dSeoul Sleep Center, Seoul 06041, Republic of Korea
eGreen Store Inc., R&D Center, Seoul 08501, Republic of Korea
fDepartment of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, 1975 Zonal Avenue, Los Angeles, CA 90033, USA
Corresponding authors: Jang H. Youn, Suengmok Cho
aDepartment of Food Science and Technology, Institute of Food Science, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea
bResearch & Development Center, Nutra-it Inc., 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea
cResearch Division of Food Functionality, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-meyon, Wanju, Jeonbuk 55365, Republic of Korea
dSeoul Sleep Center, Seoul 06041, Republic of Korea
eGreen Store Inc., R&D Center, Seoul 08501, Republic of Korea
fDepartment of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, 1975 Zonal Avenue, Los Angeles, CA 90033, USA
Corresponding authors: Jang H. Youn, Suengmok Cho
Abstract
Background
Citrus peels are rich in flavonoids with potential sedative-hypnotic effects; however, these effects have not yet been fully explored. We previously demonstrated that, in mice, standardized lime peel supplement (SLPS) induced non-rapid eye movement sleep and shortened sleep latency through GABAA receptors activation.
Purpose and Study Design
This study aimed to evaluate the effects of SLPS in adults experiencing sleep disturbances. The randomized, double-blind, placebo-controlled clinical trial involved 80 subjects who received either SLPS (300 mg/day) or placebo for a 2-week period.
Results
SLPS significantly improved polysomnographic outcomes, including a reduction in sleep latency, wake after sleep onset, and total wake time, and enhancement of sleep efficiency, total sleep time, and stage 2 sleep. Daytime sleepiness, assessed via the Epworth Sleepiness Scale, was also decreased by SLPS.
Conclusion
No serious adverse effects or side effects were reported among participants in the SLPS group during the intervention period. Our findings support SLPS as a potential natural sleep aid for improving sleep in adults with sleep disturbance.
Citrus peels are rich in flavonoids with potential sedative-hypnotic effects; however, these effects have not yet been fully explored. We previously demonstrated that, in mice, standardized lime peel supplement (SLPS) induced non-rapid eye movement sleep and shortened sleep latency through GABAA receptors activation.
Purpose and Study Design
This study aimed to evaluate the effects of SLPS in adults experiencing sleep disturbances. The randomized, double-blind, placebo-controlled clinical trial involved 80 subjects who received either SLPS (300 mg/day) or placebo for a 2-week period.
Results
SLPS significantly improved polysomnographic outcomes, including a reduction in sleep latency, wake after sleep onset, and total wake time, and enhancement of sleep efficiency, total sleep time, and stage 2 sleep. Daytime sleepiness, assessed via the Epworth Sleepiness Scale, was also decreased by SLPS.
Conclusion
No serious adverse effects or side effects were reported among participants in the SLPS group during the intervention period. Our findings support SLPS as a potential natural sleep aid for improving sleep in adults with sleep disturbance.
논문정보
- Research article
- 2025년 02월 (BRIC 등록일 2025-02-19)
- 국내(교신)+국외 연구진
- 생명과학 > 식품학
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