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Mol. Cancer, Feb 14 2025, 24 (1) 47 | https://doi.org/10.1186/s12943-025-02250-9
Towards understanding cancer dormancy over strategic hitching up mechanisms to technologies
Sumin Yang 1†, Jieun Seo 2,3†, Jeonghyeon Choi 1†, Sung-Hyun Kim 1, Yunmin Kuk 2,3, Kyung Chan Park 2,3, Mingon Kang 4, Sangwon Byun 2,3* and Jae-Yeol Joo 1,5*
1Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 15588, Korea
2Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
3Department of Functional Genomics, University of Science and Technology, Daejeon 34113, Korea
4Department of Computer Science, University of Nevada, Las Vegas, NV 89154, USA
5Department of Pharmacy, College of Pharmacy, Hanyang University, Rm 407, Bldg.42, 55 Hanyangdaehak-ro, Sangnok-gu Ansan, Gyeonggi-do 15588, Republic of Korea
2Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
3Department of Functional Genomics, University of Science and Technology, Daejeon 34113, Korea
4Department of Computer Science, University of Nevada, Las Vegas, NV 89154, USA
5Department of Pharmacy, College of Pharmacy, Hanyang University, Rm 407, Bldg.42, 55 Hanyangdaehak-ro, Sangnok-gu Ansan, Gyeonggi-do 15588, Republic of Korea
†Sumin Yang, Jieun Seo and Jeonghyeon Choi contributed equally to this work.
*Corresponding author: correspondence to Sangwon Byun or Jae-Yeol Joo
*Corresponding author: correspondence to Sangwon Byun or Jae-Yeol Joo
Abstract
Delving into cancer dormancy has been an inherent task that may drive the lethal recurrence of cancer after primary tumor relief. Cells in quiescence can survive for a short or long term in silence, may undergo genetic or epigenetic changes, and can initiate relapse through certain contextual cues. The state of dormancy can be induced by multiple conditions including cancer drug treatment, in turn, undergoes a life cycle that generally occurs through dissemination, invasion, intravasation, circulation, immune evasion, extravasation, and colonization. Throughout this cascade, a cellular machinery governs the fate of individual cells, largely affected by gene regulation. Despite its significance, a precise view of cancer dormancy is yet hampered. Revolutionizing advanced single cell and long read sequencing through analysis methodologies and artificial intelligence, the most recent stage in the research tool progress, is expected to provide a holistic view of the diverse aspects of cancer dormancy.
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- Review Paper
- 2025년 02월 (BRIC 등록일 2025-02-18)
- 국내(교신)+국외 연구진
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