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한빛사논문
- 조회195
Chem. Rev., Feb 14 2025, | https://doi.org/10.1021/acs.chemrev.4c00546
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy
Wei Xu 1,2, Guoqiang Guan 2,3, Renye Yue 2,4, Zhe Dong 2, Lingling Lei 2,5, Heemin Kang 6, Guosheng Song 2
1School of Life Science and Technology, Shandong Second Medical University, Weifang 261053, PR China.
2State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
3Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
4School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR China.
5School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, PR China.
6Department of Materials Science and Engineering and College of Medicine, Korea University, 12 Seoul 02841, Republic of Korea.
Corresponding Authors : Heemin Kang, Guosheng Song
1School of Life Science and Technology, Shandong Second Medical University, Weifang 261053, PR China.
2State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
3Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
4School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR China.
5School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, PR China.
6Department of Materials Science and Engineering and College of Medicine, Korea University, 12 Seoul 02841, Republic of Korea.
Corresponding Authors : Heemin Kang, Guosheng Song
Abstract
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, its clinical application in oncology is currently limited by issues such as suboptimal efficacy and potential off-target effects. The advent of nanotechnology has provided a new way for overcoming these challenges through the development of activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed to improve the specificity and efficacy of ferroptosis induction. This Review delves into the chemical and biological principles guiding the design of MNPs for ferroptosis-based cancer therapies and imaging-guided therapies. It discusses the regulatory mechanisms and biological attributes of ferroptosis, the chemical composition of MNPs, their mechanism of action as ferroptosis inducers, and their integration with advanced imaging techniques for therapeutic monitoring. Additionally, we examine the convergence of ferroptosis with other therapeutic strategies, including chemodynamic therapy, photothermal therapy, photodynamic therapy, sonodynamic therapy, and immunotherapy, within the context of nanomedicine strategies utilizing MNPs. This Review highlights the potential of these multifunctional MNPs to surpass the limitations of conventional treatments, envisioning a future of drug-resistance-free, precision diagnostics and ferroptosis-based therapies for treating recalcitrant cancers.
논문정보
- Review Paper
- 2025년 02월 (BRIC 등록일 2025-02-18)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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