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Biomaterials, Available online 28 January 2025, 123136 | https://doi.org/10.1016/j.biomaterials.2025.12313
Engineering Multifunctional Surface Topography to Regulate Multiple Biological Responses
Mohammad Asadi Tokmedash 1, Changheon Kim 1, Ajay P. Chavda 1, Adrian Li 1, Jacob Robins 1, Jouha Min 1,2,3,4,5
1Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109
3Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109
4Rogel Cancer Center, University of Michigan, C Arbor, MI 48109
5Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI 48109
Corresponding author: Jouha Min, PhD
1Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109
3Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109
4Rogel Cancer Center, University of Michigan, C Arbor, MI 48109
5Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI 48109
Corresponding author: Jouha Min, PhD
Abstract
Surface topography or curvature plays a crucial role in regulating cell behavior, influencing processes such as adhesion, proliferation, and gene expression. Recent advancements in nano- and micro-fabrication techniques have enabled the development of biomimetic systems that mimic native extracellular matrix (ECM) structures, providing new insights into cell-adhesion mechanisms, mechanotransduction, and cell-environment interactions. This review examines the diverse applications of engineered topographies across multiple domains, including antibacterial surfaces, immunomodulatory devices, tissue engineering scaffolds, and cancer therapies. It highlights how nanoscale features like nanopillars and nanospikes exhibit bactericidal properties, while many microscale patterns can direct stem cell differentiation and modulate immune cell responses. Furthermore, we discuss the interdisciplinary use of topography for combined applications, such as the simultaneous regulation of immune and tissue cells in 2D and 3D environments. Despite significant advances, key knowledge gaps remain, particularly regarding the effects of topographical cues on multicellular interactions and dynamic 3D contexts. This review summarizes current fabrication methods, explores specific and interdisciplinary applications, and proposes future research directions to enhance the design and utility of topographically patterned biomaterials in clinical and experimental settings.
논문정보
- Research article
- 2025년 01월 (BRIC 등록일 2025-02-18)
- 국외 연구진
- 생명과학 > 생물공학
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