한빛사
>
한빛사논문
한빛사논문
1
- 조회263
Phytomedicine, Available online 8 February 2025, 156457 | https://doi.org/10.1016/j.phymed.2025.156457
L-theanine ameliorates traumatic-brain-injury-induced hippocampal neuronal death in rats
Min Kyu Park 1, Bo Young Choi 2,3, A Ra Kho 4,5, Song Hee Lee 1, Dae Ki Hong 1,5, Beom Seok Kang 1, Chang Jun Lee 1, Hyun Wook Yang 1, Seo Young Woo 1, Se Wan Park 1, Dong Yeon Kim 1, Hyun Ho Jung 1, Won il Yang 2,3,6, Sang Won Suh 1
1Department of Physiology, Neurology, Hallym University, College of Medicine, 1-Okcheon Dong, 39 Hallymdaehak-gil, Chuncheon, 200-708, Republic of Korea
2Institute of Sport Science, Hallym University, Chuncheon, 24252, Korea
3Department of Physical Education, Hallym University, Chuncheon, 24252, Korea
4Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
5Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA
6Department of Sport Industry Studies, Yonsei University, Seoul, 03722, Republic of Korea
Corresponding author : Sang Won Suh
1Department of Physiology, Neurology, Hallym University, College of Medicine, 1-Okcheon Dong, 39 Hallymdaehak-gil, Chuncheon, 200-708, Republic of Korea
2Institute of Sport Science, Hallym University, Chuncheon, 24252, Korea
3Department of Physical Education, Hallym University, Chuncheon, 24252, Korea
4Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
5Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA
6Department of Sport Industry Studies, Yonsei University, Seoul, 03722, Republic of Korea
Corresponding author : Sang Won Suh
Abstract
Background
Traumatic brain injury (TBI) is a major health concern, often resulting in significant brain damage and functional impairments. A key contributing factor to TBI-induced neuronal injury is the overactivation of AMPA glutamate receptors, leading to an increased influx of calcium and zinc ions. This study investigates the neuroprotective potential of L-theanine, known for its antioxidant potential and ability to enhance glutathione synthesis, against hippocampal damage in a TBI rat model.
Traumatic brain injury (TBI) is a major health concern, often resulting in significant brain damage and functional impairments. A key contributing factor to TBI-induced neuronal injury is the overactivation of AMPA glutamate receptors, leading to an increased influx of calcium and zinc ions. This study investigates the neuroprotective potential of L-theanine, known for its antioxidant potential and ability to enhance glutathione synthesis, against hippocampal damage in a TBI rat model.
Methods
Rats subjected to TBIs were treated with two dosages of L-theanine (100 and 200 mg/kg) and an AMPA receptor inhibitor, NBQX (30 mg/kg). The neuronal damage assessment, conducted 24 hours post-injury, involved a histological analysis, focusing on the factors of neuronal death, oxidative damage, and glial cell activation. The statistical analysis included the performance of an ANOVA followed by a Bonferroni post hoc test, with the data presented as mean ± SEM values and the significance determined at p < 0.05.
Results
Treatment with L-theanine was observed to significantly mitigate the zinc accumulation, neuronal death, and cognitive impairments associated with TBI. These benefits are likely attributed to the inhibition of AMPA receptor activity and reduction in neuroinflammation, possibly enhanced as a result of increased glutathione production.
Conclusion
This study suggests that L-theanine can perform a neuroprotective role in TBI, modulating AMPA receptor activation and diminishing neuroinflammation. Its antioxidant and anti-inflammatory properties further enhance the material's potential use as a therapeutic agent for reducing hippocampal damage caused as a result of a TBI.
논문정보
- Research article
- 2025년 02월 (BRIC 등록일 2025-02-12)
- 국내(교신)+국외 연구진
- 의약학 > 신경의학
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
