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김명지Myungji Kim
POSTECH
Nat. Commun., Feb 07 2025, 16 (1) 1430 | https://doi.org/10.1038/s41467-025-56665-5
Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets
Myungji Kim1, Seungyeon Cho2, Dong Gyu Hwang2, In Kyong Shim3, Song Cheol Kim3,4, Jiwon Jang2,5 & Jinah Jang1,2,5,6,7,8
1Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
2Center for 3D Organ Printing and Stem Cells, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
3Asan Institute for Life Science, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
4Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
5Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
6Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
7Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
8Institute for Convergence Research and Education in Advanced Technology, Yonsei University, Seoul, Republic of Korea.
Corresponding author
Correspondence to Jinah Jang.
1Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
2Center for 3D Organ Printing and Stem Cells, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
3Asan Institute for Life Science, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
4Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
5Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
6Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
7Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
8Institute for Convergence Research and Education in Advanced Technology, Yonsei University, Seoul, Republic of Korea.
Corresponding author
Correspondence to Jinah Jang.
Abstract
Pancreatic islets are densely packed cellular aggregates containing various hormonal cell types essential for blood glucose regulation. Interactions among these cells markedly affect the glucoregulatory functions of islets along with the surrounding niche and pancreatic tissue-specific geometrical organization. However, stem cell (SC)-derived islets generated in vitro often lack the three-dimensional extracellular microenvironment and peri-vasculature, which leads to the immaturity of SC-derived islets, reducing their ability to detect glucose fluctuations and insulin release. Here, we bioengineer the in vivo-like pancreatic niches by optimizing the combination of pancreatic tissue-specific extracellular matrix and basement membrane proteins and utilizing bioprinting-based geometrical guidance to recreate the spatial pattern of islet peripheries. The bioprinted islet-specific niche promotes coordinated interactions between islets and vasculature, supporting structural and functional features resembling native islets. Our strategy not only improves SC-derived islet functionality but also offers significant potential for advancing research on islet development, maturation, and diabetic disease modeling, with future implications for translational applications.
논문정보
- Research article
- 2025년 02월 (BRIC 등록일 2025-02-17)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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