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한빛사논문

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한국뇌연구원

Biosens. Bioelectron., Jan 22 2025, 274 S0956-5663(25)00070-3 | https://doi.org/10.1016/j.bios.2025.117196 ECoGScope: An integrated platform for real-time Electrophysiology and fluorescence imaging

Jonghee Eun ^a,#, Jeongseop Kim ^a,#, Tae-Eun Kim ^a,b, Ja Wook Koo^a,b, Namsun Chou ^a,1
^aEmotion, Cognition, & Behavior Research Group, Korea Brain Research Institute 61, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea
^bDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea

Corresponding authors: Ja Wook Koo, Namsun Chou
^#These authors contributed equally.
¹Lead contact.

Abstract

In this study, we present ECoGScope, a versatile neural interface platform designed to integrate multiple functions for advancing neural network research. ECoGScope combines an electrocorticography (ECoG) electrode array with a commercial microendoscope, enabling simultaneous recording of ECoG signals and fluorescence imaging. The electrode array, constructed from highly flexible and transparent polymers, ensures conformal contact with the brain surface, allowing unobstructed optical monitoring of neural activity alongside electrophysiological recordings. A key innovation is the compact connection module, which securely integrates the ECoG array and microendoscope while minimizing interference with animal behavior. The device was successfully tested in the visual, somatosensory, and frontal cortex, demonstrating its capability for simultaneous electrophysiological and fluorescent measurements. These results highlight the potential of the ECoGScope platform to advance the development of multifunctional tools for studying brain function and addressing neurological disorders.

논문정보

형식Research article
게재일2025년 01월 (BRIC 등록일 2025-02-03)
연구진국내 연구진
분야 바이오·의료융합 > 뇌인지과학

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