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Crit. Rev. Food Sci. Nutr., Jan 29 2025, | https://doi.org/10.1080/10408398.2025.2458755
Mechanistic and bibliometric insights into RpoS-mediated biofilm regulation and its strategic role in food safety applications
Shirin Akter 1,2,3, Md Ashikur Rahman 1,2,4, Md Ashrafudoulla 1,5,6, A G M Sofi Uddin Mahamud 1, Md Anamul Hasan Chowdhury 1,2, Sang-Do Ha 1,2
1Food Safety and Regulatory Science, Chung-Ang University, Anseong-Si, Republic of Korea.
2GreenTech-Based Food Safety Research Group, Chung-Ang University, Anseong, Republic of Korea.
3Department of Fisheries and Marine Bioscience, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
4Bangladesh Fisheries Research Institute, Mymensingh, Bangladesh.
5National Institutes of Health, Bethesda, MD, USA.
6Department of Food Science, Center for Food Safety, University of Arkansas System Division of Agriculture, Fayetteville, AR, USA.
Correspondence : Sang-Do Ha
1Food Safety and Regulatory Science, Chung-Ang University, Anseong-Si, Republic of Korea.
2GreenTech-Based Food Safety Research Group, Chung-Ang University, Anseong, Republic of Korea.
3Department of Fisheries and Marine Bioscience, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
4Bangladesh Fisheries Research Institute, Mymensingh, Bangladesh.
5National Institutes of Health, Bethesda, MD, USA.
6Department of Food Science, Center for Food Safety, University of Arkansas System Division of Agriculture, Fayetteville, AR, USA.
Correspondence : Sang-Do Ha
Abstract
Biofilm, complex structures formed by microorganisms within an extracellular polymeric matrix, pose significant challenges in the sector by harboring dangerous pathogens and complicating decontamination, thereby increasing the risk of foodborne illnesses. This article provides a comprehensive review of the sigma factor, rpoS's role in biofilm development, specifically in gram-negative bacteria, and how the genetic, environmental, and regulatory elements influence rpoS activity with its critical role in bacterial stress responses. Our findings reveal that rpoS is a pivotal regulator of biofilm formation, enhancing bacterial survival in adverse conditions. Key factors affecting rpoS activity include oxidative and osmotic stress and nutrient availability. Understanding rpoS-mediated regulatory pathways is essential for developing targeted biofilm management strategies to improve food quality and safety. Furthermore, a bibliometric analysis highlights significant research trends and gaps in the literature, guiding future research directions. Future research should focus on detailed mechanistic studies of rpoS-mediated biofilm regulation, the development of specific rpoS inhibitors, and innovative approaches like biofilm-resistant surface coatings. This knowledge can lead to more effective contamination prevention and overall food safety enhancements.
논문정보
- Review Paper
- 2025년 01월 (BRIC 등록일 2025-02-01)
- 국내(교신)+국외 연구진
- 생명과학 > 식품학
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